| Implications of High Free Thyroxine (FT4) Concentrations in Euthyroid Pregnancies: The FaSTER Trial. | |
MedLine Citation:
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PMID: 24606107 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context: Lower birthweight has been reported in conjunction with high maternal free thyroxine (FT4) in euthyroid pregnancies, raising concerns for suboptimal outcomes. Objective: Explore relationships between high maternal FT4 and pregnancy complications in euthyroid women. Further examine relationships among maternal size, FT4 and birthweight. Design: Observational multicenter cohort study. Setting: Prenatal clinics. Study Subjects: 9209 euthyroid women with singleton pregnancies. Interventions: None. Main Outcome Measures: Relationships between second trimester high maternal FT4 and pregnancy/delivery complications, and among FT4, maternal weight and birthweight. Results: Women in the highest FT4 quintile are younger and weigh less than women in quintiles 1-4; gestational diabetes and preeclampsia occur less often (p = < 0.001, < 0.001, < 0.001, and 0.05, respectively). Lowest median birthweight occurs among women in the highest FT4 quintile (p = < 0.001), but deliveries < 37 weeks' gestation are not increased. Labor/delivery complications do not differ by FT4 quintile. Restricting analyses to maternal weight-adjusted small-for-gestational-age deliveries yields similar results, except for preeclampsia. In the highest maternal weight decile, adjusted median birthweight is 266g higher (8.3%) than in the lowest weight decile; adjusted median FT4 is 0.91 pmol/L lower (6.8%). Among women in the highest FT4 decile, adjusted median birthweight is 46g lower (1.3%) than in the lowest FT4 decile. All three relationships are statistically significant (p = < 0.001, < 0.001, and 0.004, respectively). Conclusions: Lower median birthweight among euthyroid women with high FT4 is not associated with adverse pregnancy outcomes. Further investigation is indicated to determine how variations in thyroid hormone concentration influence birthweight. |
Authors:
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James E Haddow; Wendy Y Craig; Louis M Neveux; Hamish R M Haddow; Glenn E Palomaki; Geralyn Lambert-Messerlian; Fergal D Malone; Mary E D'Alton; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2014-2-28 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2014 Feb |
Date Detail:
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Created Date: 2014-3-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: jc20141053 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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