Document Detail


Implication of protein aromatic amino acids in concanavalin A-carbohydrate interactions. A radiolytic study.
MedLine Citation:
PMID:  304848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulse radiolysis and 60Co gamma-radiolysis have been used to study the effects of ionizing radiation on the glycogen-precipitating activity of the protein concanavalin A. Both eaq- and OH. react extremely rapidly with the protein and contribute to the observed loss of concanavalin A activity. Evidence is also presented that (Br)2-. and (SCN)2-. react with with tyrosine and tryptophan residues in concanavalin A, which is also accompanied by loss of glycogen precipitation activity.
Authors:
J V Davies; J S Moore; S Mudher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation biology and related studies in physics, chemistry, and medicine     Volume:  33     ISSN:  0020-7616     ISO Abbreviation:  Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0374725     Medline TA:  Int J Radiat Biol Relat Stud Phys Chem Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  11-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cobalt Radioisotopes
Concanavalin A* / radiation effects
Dose-Response Relationship, Radiation
Gamma Rays
Glycogen*
Pulse Radiolysis
Receptors, Concanavalin A / radiation effects
Tryptophan*
Tyrosine*
Chemical
Reg. No./Substance:
0/Cobalt Radioisotopes; 0/Receptors, Concanavalin A; 11028-71-0/Concanavalin A; 55520-40-6/Tyrosine; 73-22-3/Tryptophan; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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