Document Detail


Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin.
MedLine Citation:
PMID:  23390091     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Among the PC family members, only furin activates hepcidin in hepatocytes, and uniquely the full-length membrane-bound PC7 can directly shed hTfR1 by cleavage at Arg100 ↓. Our results support the notion that, when iron is limiting, hTfR1 levels increase at least in part by way of the down-regulation of PC7 expression. (HEPATOLOGY 2013;).
Authors:
Johann Guillemot; Maryssa Canuel; Rachid Essalmani; Annik Prat; Nabil G Seidah
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-05-15
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-13     Completed Date:  2013-08-16     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2514-24     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD / metabolism*
Antimicrobial Cationic Peptides / metabolism*
COS Cells
Cercopithecus aethiops
Down-Regulation
Endosomes / metabolism
Furin / metabolism*
HEK293 Cells
Hep G2 Cells
Hepatocytes / metabolism*
Hepcidins
Humans
Iron / metabolism*
Mice
Protein Structure, Tertiary
Receptors, Transferrin / metabolism*
Subtilisins / metabolism*
Grant Support
ID/Acronym/Agency:
MOP-44363//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antimicrobial Cationic Peptides; 0/CD71 antigen; 0/HAMP protein, human; 0/Hamp1 protein, mouse; 0/Hepcidins; 0/Receptors, Transferrin; E1UOL152H7/Iron; EC 3.4.21.-/Subtilisins; EC 3.4.21.-/proprotein convertase PC7; EC 3.4.21.75/Furin
Comments/Corrections
Comment In:
Hepatology. 2013 Nov;58(5):1860-1   [PMID:  23504908 ]
Hepatology. 2013 Nov;58(5):1861-2   [PMID:  23505014 ]

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