Document Detail

Implication of the negative U wave during dobutamine stress echocardiography.
MedLine Citation:
PMID:  9005887     Owner:  NLM     Status:  MEDLINE    
Although the development of negative U waves during exercise is a highly specific marker for detecting coronary artery disease, their assessment during exercise is difficult. The clinical significance of the negative U wave during dobutamine stress echocardiography was investigated in 181 patients who had suspected coronary artery disease. Dobutamine-induced negative U waves appeared in 28 patients (16%) during dobutamine infusion. Coronary angiography showed coronary artery disease in 114 of the 181 patients. The sensitivity and specificity of the negative U wave for detecting coronary artery disease were 22 and 96%, respectively, while the corresponding values for ischemic ST-T changes were 49 and 76%, respectively. The negative U wave appeared during low-dose infusion of dobutamine (5-10 microg/kg/min) in 82% of the patients with this wave. In the 21 patients who had both a negative U wave and an inducible regional wall motion abnormality during dobutamine infusion, the development of the negative U wave was either simultaneous with or earlier than that of the wall motion abnormality. Although its sensitivity was low, the negative U wave during dobutamine stress echocardiography is a highly specific marker for detecting coronary artery disease. Because of its earlier appearance as compared with that of the wall motion abnormality, the dobutamine-induced negative U wave may be considered to be an early and useful adjunctive sign for detecting coronary artery disease during dobutamine stress echocardiography.
Y Miura; M Takeuchi; S Sonoda; Y Nakashima; A Kuroiwa
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of electrocardiology     Volume:  30     ISSN:  0022-0736     ISO Abbreviation:  J Electrocardiol     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-14     Completed Date:  1997-04-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
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MeSH Terms
Cardiotonic Agents / administration & dosage,  diagnostic use*
Coronary Angiography
Coronary Disease / diagnosis*,  physiopathology
Dobutamine / administration & dosage,  diagnostic use*
Dose-Response Relationship, Drug
Echocardiography / methods*
Middle Aged
Retrospective Studies
Sensitivity and Specificity
Stress, Physiological / chemically induced*,  ultrasonography
Ventricular Dysfunction, Left / chemically induced,  physiopathology,  ultrasonography
Reg. No./Substance:
0/Cardiotonic Agents; 34368-04-2/Dobutamine

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