| Implication of the negative U wave during dobutamine stress echocardiography. | |
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MedLine Citation:
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PMID: 9005887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the development of negative U waves during exercise is a highly specific marker for detecting coronary artery disease, their assessment during exercise is difficult. The clinical significance of the negative U wave during dobutamine stress echocardiography was investigated in 181 patients who had suspected coronary artery disease. Dobutamine-induced negative U waves appeared in 28 patients (16%) during dobutamine infusion. Coronary angiography showed coronary artery disease in 114 of the 181 patients. The sensitivity and specificity of the negative U wave for detecting coronary artery disease were 22 and 96%, respectively, while the corresponding values for ischemic ST-T changes were 49 and 76%, respectively. The negative U wave appeared during low-dose infusion of dobutamine (5-10 microg/kg/min) in 82% of the patients with this wave. In the 21 patients who had both a negative U wave and an inducible regional wall motion abnormality during dobutamine infusion, the development of the negative U wave was either simultaneous with or earlier than that of the wall motion abnormality. Although its sensitivity was low, the negative U wave during dobutamine stress echocardiography is a highly specific marker for detecting coronary artery disease. Because of its earlier appearance as compared with that of the wall motion abnormality, the dobutamine-induced negative U wave may be considered to be an early and useful adjunctive sign for detecting coronary artery disease during dobutamine stress echocardiography. |
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Authors:
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Y Miura; M Takeuchi; S Sonoda; Y Nakashima; A Kuroiwa |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of electrocardiology Volume: 30 ISSN: 0022-0736 ISO Abbreviation: J Electrocardiol Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-04-14 Completed Date: 1997-04-14 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 57-64 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiotonic Agents / administration & dosage, diagnostic use* Coronary Angiography Coronary Disease / diagnosis*, physiopathology Dobutamine / administration & dosage, diagnostic use* Dose-Response Relationship, Drug Echocardiography / methods* Electrocardiography Female Humans Male Middle Aged Retrospective Studies Sensitivity and Specificity Stress, Physiological / chemically induced*, ultrasonography Ventricular Dysfunction, Left / chemically induced, physiopathology, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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