Document Detail


Implication of intercellular adhesion molecule-1 (ICAM-1) and serum N(G)-hydroxy-L-arginine (L-NHA) in the pathogenesis of systemic sclerosis.
MedLine Citation:
PMID:  15719609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a trial to throw light on the implication of intercellular adhesion molecule-1 (ICAM-1) and N(G)-hydroxy-L-arginine (L-NHA) in the pathogenesis of systemic sclerosis or Scleroderma, (SSc), their serum levels were estimated in twenty SSc patients using ELISA and high performance liquid chromatography respectively. In situ "local" expression of ICAM-1 in lesional skin of these patients was also assessed using biotinstreptavidin amplified detection system. Patients were divided into 3 groups according to the cutaneous extension of sclerosis (Grades I; II & III). A significant (P < 0.001) difference was found between patients (n = 20) and controls (n = 10) regarding soluble ICAM-1 (s ICAM-1) and L-NHA levels. Among patients, a significant difference (P < 0.001, 0.05 respectively) in sICAM-1 & L-NHA serum levels was found between patients who had musculoskeletal manifestations and those who had not. A significant (P < 0.001) difference in L-NHA level was found between patients with grade I, II, III. Among patients, there was a negative correlation (r = -0.413) between serum sICAM-1 and the duration of the disease, and a positive correlation (r = +0.514) between sICAM-1 and L-NHA serum levels. 4 patients (23.6%) showed mild immunostaining, 8 patients (47%) showed moderate staining, and 5 patients (29.4%) showed intense staining, while control specimens showed negative immunostaining. In conclusion, ICAM-1 and serum L-NHA are probably implicated in the pathogenesis of SSc. Elevated sICAM-1 and L-NHA serum could be used as a quantitative marker of tissue sclerosis, allowing better follow up of patients.
Authors:
Mona Lotfy Zamzam; Manal Mohamed Yassin; Maha Mohamed Sallam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Egyptian journal of immunology / Egyptian Association of Immunologists     Volume:  10     ISSN:  1110-4902     ISO Abbreviation:  Egypt J Immunol     Publication Date:  2003  
Date Detail:
Created Date:  2005-02-21     Completed Date:  2005-03-18     Revised Date:  2008-02-11    
Medline Journal Info:
Nlm Unique ID:  9816016     Medline TA:  Egypt J Immunol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  27-38     Citation Subset:  IM    
Affiliation:
Department of Physical Medicine and Rehabilitation, Ain Shams University, Cairo, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arginine / analogs & derivatives*,  blood*
Biological Markers / blood
Case-Control Studies
Female
Humans
Intercellular Adhesion Molecule-1 / blood,  metabolism*
Male
Middle Aged
Scleroderma, Systemic / blood,  etiology*,  immunology*,  pathology
Skin / immunology,  pathology
Solubility
Chemical
Reg. No./Substance:
0/Biological Markers; 126547-89-5/Intercellular Adhesion Molecule-1; 53054-07-2/N(omega)-hydroxyarginine; 74-79-3/Arginine

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