Document Detail

Implication of the central nervous system in the systemic and regional hemodynamics of two centrally acting hypotensive drugs, flesinoxan and clonidine, in the rat.
MedLine Citation:
PMID:  1724539     Owner:  NLM     Status:  MEDLINE    
The systemic and regional hemodynamic effects of the selective 5-HT1A receptor agonist flesinoxan (3-300 micrograms/kg, i.v., in cumulative doses) were investigated in normotensive anesthetized and pithed rats using a pulsed Doppler system and were compared to those of the alpha 2-adrenoceptor agonist clonidine. In anesthetized rats, flesinoxan and clonidine induced dose-dependent decreases in blood pressure and heart rate. Total peripheral resistance and hindquarters vascular resistance dose-dependently decreased after flesinoxan administration whereas cardiac output remained unchanged. Clonidine dose-dependently decreased cardiac output and did not change total peripheral resistance. These results indicate that the decrease in blood pressure induced by flesinoxan is due to a reduction in total peripheral and hindquarters vascular resistance. In contrast, clonidine decreased blood pressure by reducing cardiac output. In the pithed rat, the systemic and regional hemodynamic effects of flesinoxan were abolished whereas those of clonidine were reversed. These results provide evidence for the participation of the central nervous system in the systemic and regional hemodynamic effects of flesinoxan. However, direct administration into the central nervous system remains to be performed in order to strengthen this conclusion.
H Dabiré; C Richer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  18     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-04-07     Completed Date:  1992-04-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  605-13     Citation Subset:  IM    
INSERM U337, Faculté de Médecine Broussais Hôtel-Dieu, Paris, France.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects
Cardiac Output / drug effects
Central Nervous System / physiology*
Clonidine / pharmacology*
Decerebrate State / physiopathology
Dose-Response Relationship, Drug
Heart Rate / drug effects
Hemodynamics / drug effects*
Piperazines / pharmacology*
Rats, Inbred Strains
Regional Blood Flow / drug effects*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Antihypertensive Agents; 0/Piperazines; 4205-90-7/Clonidine; 98206-10-1/flesinoxan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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