| Implication of the age in the clinical spectrum of giant cell arteritis. | |
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MedLine Citation:
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PMID: 18799048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the potential influence of the age in the clinical spectrum of giant cell arteritis (GCA). METHODS: The case records of all patients diagnosed with biopsy-proven GCA at the Department of Medicine of the Hospital Xeral-Calde (Lugo, Northwest Spain) between 1981 and 2006 were reviewed. RESULTS: During the period of study, 273 Lugo residents were diagnosed with biopsy-proven GCA. The mean age +/- standard deviation at the time of disease diagnosis was 75.1+/-6.8 years (median: 75 years; interquartile range 71-80 years). A longer delay to the diagnosis was observed in patients younger than 70 years of age (13.2+/-12.8 weeks) compared to those 70 years and older (9.4+/-10.2 weeks) (p=0.03). Patients younger than 70 years presented more frequently polymyalgia rheumatica (p=0.02), cerebrovascular accidents (p=0.004), peripheral arteriopathy of recent onset due to large artery stenosis (p=0.03) and high alkaline phosphatase values (p=0.001) than those 70 years and older. Individuals 70-79 years of age at the time of disease diagnosis had ESR values (90.2+/-22.8 mm/1st hour) lower than those observed in patients younger than 70 years (98.3+/-22.2 mm/1st hour) or 80 years and older (99.5+/-20.6 mm/1st hour) (p=0.005). However, no significant differences in the frequency of visual ischemic complications according to the age at the time of disease diagnosis were observed. CONCLUSION: The results from this study display differences in the clinical spectrum of the disease according to the age of disease onset. |
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Authors:
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M J Lopez-Diaz; J Llorca; C Gonzalez-Juanatey; J L Peña-Sagredo; J Martin; M A Gonzalez-Gay |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: 26 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 2008 May-Jun |
Date Detail:
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Created Date: 2008-09-18 Completed Date: 2009-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: Italy |
Other Details:
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Languages: eng Pagination: S16-22 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Hospital Xeral-Calde, Lugo, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Aged, 80 and over Biopsy Blood Sedimentation Cohort Studies Disease Progression Female Giant Cell Arteritis / diagnosis*, pathology*, physiopathology Humans Male Middle Aged Polymyalgia Rheumatica / diagnosis, physiopathology Retrospective Studies Temporal Arteries / pathology* |
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