Document Detail


Implication of the age in the clinical spectrum of giant cell arteritis.
MedLine Citation:
PMID:  18799048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the potential influence of the age in the clinical spectrum of giant cell arteritis (GCA). METHODS: The case records of all patients diagnosed with biopsy-proven GCA at the Department of Medicine of the Hospital Xeral-Calde (Lugo, Northwest Spain) between 1981 and 2006 were reviewed. RESULTS: During the period of study, 273 Lugo residents were diagnosed with biopsy-proven GCA. The mean age +/- standard deviation at the time of disease diagnosis was 75.1+/-6.8 years (median: 75 years; interquartile range 71-80 years). A longer delay to the diagnosis was observed in patients younger than 70 years of age (13.2+/-12.8 weeks) compared to those 70 years and older (9.4+/-10.2 weeks) (p=0.03). Patients younger than 70 years presented more frequently polymyalgia rheumatica (p=0.02), cerebrovascular accidents (p=0.004), peripheral arteriopathy of recent onset due to large artery stenosis (p=0.03) and high alkaline phosphatase values (p=0.001) than those 70 years and older. Individuals 70-79 years of age at the time of disease diagnosis had ESR values (90.2+/-22.8 mm/1st hour) lower than those observed in patients younger than 70 years (98.3+/-22.2 mm/1st hour) or 80 years and older (99.5+/-20.6 mm/1st hour) (p=0.005). However, no significant differences in the frequency of visual ischemic complications according to the age at the time of disease diagnosis were observed. CONCLUSION: The results from this study display differences in the clinical spectrum of the disease according to the age of disease onset.
Authors:
M J Lopez-Diaz; J Llorca; C Gonzalez-Juanatey; J L Peña-Sagredo; J Martin; M A Gonzalez-Gay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  26     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-09-18     Completed Date:  2009-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S16-22     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, Hospital Xeral-Calde, Lugo, Spain.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Aged, 80 and over
Biopsy
Blood Sedimentation
Cohort Studies
Disease Progression
Female
Giant Cell Arteritis / diagnosis*,  pathology*,  physiopathology
Humans
Male
Middle Aged
Polymyalgia Rheumatica / diagnosis,  physiopathology
Retrospective Studies
Temporal Arteries / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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