Document Detail


Implication of agathic acid from Utah juniper bark as an abortifacient compound in cattle.
MedLine Citation:
PMID:  19757408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Freshly ground Utah juniper [Juniperus osteosperma (Torr.) Little] bark was given via gavage at a dosage of 2.3 kg per cow twice daily to three pregnant cows starting on day 255 of gestation. All three cows aborted the calves after 4, 5 and 6 days of treatment. A fourth cow was dosed with Utah juniper needles and this cow calved early on day 268 of gestation with complications consistent with pine needle abortion. Chemical analysis of Juniperus osteosperma bark identified the major diterpene acid as the labdane acid known as agathic acid. Agathic acid was measured in the bark at a concentration of 1.5% (dry weight basis). Analysis of sera samples obtained from treated cows found detectable quantities of agathic acid, dihydroagathic acid and tetrahydroagathic acid, which are known serum metabolites of the abortifacient compound isocupressic acid. Based on the high incidence of induced abortion and detection of known metabolites in affected animals, the labdane acid known as agathic acid is considered to be an abortifacient compound in late-term pregnant cattle.
Authors:
Dale R Gardner; Kip E Panter; Bryan L Stegelmeier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  30     ISSN:  1099-1263     ISO Abbreviation:  J Appl Toxicol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  115-9     Citation Subset:  IM    
Affiliation:
USDA, ARS, PPRL, 1150 E. 1400 N., Logan, UT 84335, USA. dale.gardner@ars.usda.gov
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents / blood,  metabolism*,  pharmacology
Animals
Cattle
Dicarboxylic Acids / blood,  metabolism*,  pharmacology
Diterpenes / blood,  metabolism*,  pharmacology
Female
Humans
Juniperus / chemistry,  metabolism*
Molecular Structure
Pregnancy
Tetrahydronaphthalenes / blood,  metabolism*,  pharmacology
Utah
Chemical
Reg. No./Substance:
0/Abortifacient Agents; 0/Dicarboxylic Acids; 0/Diterpenes; 0/Tetrahydronaphthalenes; 640-28-8/agathic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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