Document Detail

Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy.
MedLine Citation:
PMID:  17217369     Owner:  NLM     Status:  MEDLINE    
PROBLEM: Several studies indicate that RANTES (regulated on activation, normal T cell expressed and secreted) is able to downregulate T-cell responses which suggest it might be relevant for fetal tolerance induction. However, the role of RANTES in pregnancy had not been established. Here we investigate RANTES regulation during early pregnancy and potential failures leading to losses of pregnancies. METHOD OF STUDY: RANTES and progesterone levels were determined in sera and feto-placental units from high resorption rate CBA/JxDBA/2 pregnant females and compared with CBA/JxBALB/c normal pregnant mice. RANTES in vitro modulation was also studied in nulliparous, primiparous and multiparous CBA/J and BALB/c cells in response to paternal alloantigen and progesterone stimulation. RESULTS: Nulliparous CBA/J females were quantitatively deficient in RANTES sera levels, whereas pregnancies with male BALB/c or DBA/2 increased its production. However, feto-placental units from CBA/J females are high producers of progesterone and RANTES. CONCLUSION: These data suggest that the beneficial effect of RANTES on feto-maternal interface requires an optimal concentration range and might be modulated by progesterone, hence exacerbated placental expression could be associated with high resorption rate.
Rosanna Ramhorst; Gabriela Gutiérrez; Adriana Corigliano; G Junovich; Leonardo Fainboim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  57     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-12     Completed Date:  2007-03-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  IM    
Division of Immunogenetics, Hospital de Clínicas José de San Martín, IDEHU, University of Buenos Aires, Argentina.
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MeSH Terms
Abortion, Spontaneous / blood,  immunology*,  metabolism
Chemokine CCL5 / blood,  immunology*,  metabolism
Mice, Inbred BALB C
Mice, Inbred CBA
Mice, Inbred DBA
Placenta / immunology,  metabolism
Progesterone / biosynthesis,  blood,  immunology*
Reg. No./Substance:
0/Chemokine CCL5; 57-83-0/Progesterone

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