Document Detail


Implication of PDGF signaling in cigarette smoke-induced pulmonary arterial hypertension in rat.
MedLine Citation:
PMID:  22746397     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pulmonary artery hypertension (PAH) is a severe disease characterized with progressive increase of pulmonary vascular resistance that finally causes right ventricular failure and premature death. Cigarette smoke (CS) is a major factor of Chronic Obstructive Pulmonary Disease (COPD) that can lead to PAH. However, the mechanism of CS-induced PAH is poorly understood. Mounting evidence supports that pulmonary vascular remodeling play an important role in the development of PAH. PDGF signaling has been demonstrated to be a major mediator of vascular remodeling implicated in PAH. However, the association of PDGF signaling with CS-induced PAH has not been documented. In this study, we investigated CS-induced PAH in rats and the expression of platelet derived growth factor (PDGF) and PDGF receptor (PDGFR) in pulmonary artery. Forty male rats were randomly divided into control group and three experimental groups that were exposed to CS for 1, 2, and 3 months, respectively. CS significantly increased right ventricular systolic pressure (RVSP) and right ventricular hypertrophy index (RVHI). Histology staining demonstrated that CS significantly increased the thickness of pulmonary artery wall and collagen deposition. The expression of PDGF isoform B (PDGF-B) and PDGF receptor beta (PDGFRβ) were significantly increased at both protein and mRNA levels in pulmonary artery of rats with CS exposure. Furthermore, Cigarette smoke extract (CSE) significantly increased rat pulmonary artery smooth muscle cell (PASMC) proliferation, which was inhibited by PDGFR inhibitor Imatinib. Thus, our data suggest PDGF signaling is implicated in CS-induced PAH.
Authors:
Ai-Ping Xing; Xiao-Yun Hu; Yi-Wei Shi; Yong-Cheng Du
Related Documents :
7374207 - Surgical anatomy of the atrioventricular valve in the intermediate type of common atrio...
11150627 - Left atrial spontaneous echo contrast in patients with rheumatic mitral valve stenosis ...
20579667 - Mitral ring annuloplasty relieves tension of the secondary but not primary chordae tend...
465207 - Echocardiographic pattern of posterior mitral valve leaflet movement after mitral valve...
1133697 - Simple isolated perfused artery preparation: vasoconstrictor evaluation.
18760127 - Intraoperative coronary artery pulse doppler patterns in patients with complete transpo...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Inhalation toxicology     Volume:  24     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  468-75     Citation Subset:  IM    
Affiliation:
Shanxi Medical University , Taiyuan , China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A chemometric analytical approach for the cloud point extraction and inductively coupled plasma mass...
Next Document:  Is calprotectin a marker of tobacco smoke related inflammation?: a pilot study in children.