Document Detail

Implication of the G145C polymorphism (rs713598) of the TAS2r38 gene on food consumption by Brazilian older women.
MedLine Citation:
PMID:  21763010     Owner:  NLM     Status:  Publisher    
To evaluate the capacity to perceive bitter taste in a sample of the elderly population of the Brazilian Federal District, and to investigate its association with the consumption profile of distinct food groups. A total of 255 female outpatients aged 60 years or older took part in this cross-sectional study. The following data were determined for all the volunteers: alimentary frequency by clinical dieticians; genotyping of the G145C polymorphism in the TAS2r38 gene; cognitive status; sensorial (visual and hearing) acuity and drugs related to ageusia or dysgeusia. Sensitivity to bitter taste was assessed using phenylthiocarbamide (PTC) in a subset. Non-parametric tests confirmed the remarkable effect of the C allele in determining sensitivity to PTC (p<0.001). C allele carriers displayed diminished consumption of type B vegetables as well as of some vegetables generally recognized as bitter: arugula (p=0.044) and chard (p=0.006). No associations were observed for the remaining food classes. The present findings suggest that the G145C genetic variation in the TAS2r38 gene modestly influenced food consumption habits of Brazilian older women. Nonetheless, the results do not rule out possible effects of past experiences on choices of elderly individuals.
Fernanda Cristina Jesus Colares-Bento; Vinicius Carolino Souza; Juliana Oliveira Toledo; Clayton Franco Moraes; Clarice Sampaio Alho; Ricardo Moreno Lima; Claudio Cordova; Otávio Toledo Nobrega
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-13
Journal Detail:
Title:  Archives of gerontology and geriatrics     Volume:  -     ISSN:  1872-6976     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214379     Medline TA:  Arch Gerontol Geriatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Universidade Católica de Brasilia, Programa de Pós-Graduação em Gerontologia, SGAN 916 - Av. W5, 70790-160, Brasilia-DF, Brazil; Faculdades Lourdes Santana, Curso de Farmácia, Setor D Sul - 5, 72.020-111, Taguatinga Sul - DF, Brazil.
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