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Implication of CKD-EPI Equation to Estimate Glomerular Filtration Rate in Chinese Patients with Chronic Kidney Disease.
MedLine Citation:
PMID:  21851197     Owner:  NLM     Status:  Publisher    
Abstract Objective: To evaluate the applicability of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation to estimate glomerular filtration rate (GFR) in Chinese patients of different stages of CKD. Methods: The CKD-EPI equation estimated GFR (eGFR) was compared with body surface area standardized GFR (sGFR), which was measured by diethylenetriaminepentaacetic acid renal dynamic imaging method in 142 CKD cases. Results: eGFR was positively correlated with sGFR (r = 0.838, p < 0.001). eGFR of 15%, 30%, and 50% accuracy were 31.0%, 57.7%, and 76.8%, respectively. Average deviation of eGFR from sGFR was -0.92 ± 16.36 mL/min/1.73 m(2) (p = 0.506). There was no significant deviation in the CKD from stages 2 to 5. However, in CKD stage 1, the deviation was increased with the value of 13.36 ± 18.44 mL/min/1.73 m(2) (p = 0.023). Conclusion: CKD-EPI equation might be widely used in evaluation of Chinese CKD patients of different stages, with a less deviation and higher accuracy. However, in CKD stage 1, eGFR was higher than sGFR on average. It was suggested that eGFR might be overcorrected or overestimated. These results demonstrated that careful modification of CKD-EPI equation would be necessary in Chinese populations with CKD.
Xin Du; Bo Hu; Linglin Jiang; Xin Wan; Li Fan; Feng Wang; Changchun Cao
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-18
Journal Detail:
Title:  Renal failure     Volume:  -     ISSN:  1525-6049     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Nephrology, Nanjing First Hospital Affiliated to Nanjing Medical University , Nanjing , PR China.
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