Document Detail

Implementing therapy with opioids in patients with cancer.
MedLine Citation:
PMID:  18980934     Owner:  NLM     Status:  MEDLINE    
PURPOSE/OBJECTIVES: To review strategies to optimize the management of chronic pain in patients with cancer, with an emphasis on the role of opioid analgesics. DATA SOURCES: Published research, articles from a literature review, and U. S. statistics. DATA SYNTHESIS: Treatment for cancer pain remains suboptimal. With the therapies currently available, as much as 90% of cancer pain can be controlled. Opioid analgesics are an important component of pain management in patients with cancer. CONCLUSIONS: The management of cancer pain is a challenging endeavor that requires an understanding of the etiologies of cancer and the types of pain they can produce. Opioid analgesics are a mainstay of treatment for cancer pain. New drug formulations, delivery systems, and strategies, particularly opioid rotation, are available to optimize cancer pain management. IMPLICATIONS FOR NURSING: Opioid rotation may be useful for opening the therapeutic window and establishing a more advantageous analgesic-to-toxicity ratio in patients with cancer.
Oscar de Leon-Casasola
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Oncology nursing forum     Volume:  35 Suppl     ISSN:  1538-0688     ISO Abbreviation:  Oncol Nurs Forum     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-04     Completed Date:  2009-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7809033     Medline TA:  Oncol Nurs Forum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM; N    
Roswell Park Cancer Institute, Buffalo, NY, USA.
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MeSH Terms
Case Management
Chronic Disease
Cognition Disorders / chemically induced
Hormones / blood
Legislation, Drug
Narcotics / administration & dosage,  adverse effects,  pharmacology,  therapeutic use*
Neoplasms / physiopathology*
Pain / drug therapy*,  etiology
Palliative Care
Prodrugs / administration & dosage,  pharmacokinetics,  therapeutic use
United States
Reg. No./Substance:
0/Hormones; 0/Narcotics; 0/Prodrugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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