Document Detail


Implementing noninvasive prenatal fetal sex determination using cell-free fetal DNA in the United Kingdom.
MedLine Citation:
PMID:  22500945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Fetal sex determination has traditionally been performed in pregnancies at risk of sex-linked genetic conditions by analysis of chorionic villi or amniocytes following invasive tests. The development of noninvasive prenatal diagnosis (NIPD) using cell-free fetal DNA in maternal plasma has allowed women to have accurate information about fetal sex early in pregnancy without the risk of miscarriage.
AREAS COVERED: In the UK, NIPD for fetal sex determination has been offered on a research basis since 2003. Formal approval and regulation through national bodies is essential to ensure standardized laboratory services, appropriate funding and equity of access for service users. Here we describe the process of formal commissioning that has been supported by a multifaceted approach to service evaluation, including appraisal of analytical and clinical validity, clinical utility and economic costs together with an exploration of service users' and providers' attitudes, preferences and information needs.
EXPERT OPINION: Implementation strategies that reach beyond the assessment of laboratory test parameters to consider psychosocial and economic issues have been crucial in bringing NIPD for fetal sex determination into routine practice. Ongoing audit and monitoring of service delivery will ensure a high standard of care is maintained.
Authors:
Melissa Hill; Celine Lewis; Lucy Jenkins; Stephanie Allen; Rob G Elles; Lyn S Chitty
Related Documents :
9491245 - A comparison of stereopsis with anvis and f4949 night vision goggles.
12011895 - The teratogenicity of drugs for nausea and vomiting of pregnancy: perceived versus true...
16945785 - Experience of taiwanese women living with nausea and vomiting during pregnancy.
16131535 - Treating pregnancy-related nausea and vomiting with ginger.
16034615 - Investigation of the species-specific degradation behaviour of methylmercury and ethylm...
14656405 - Pathophysiology of oligoasthenoteratozoospermia: are we improving in the diagnosis?
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-16
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  12 Suppl 1     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-24     Completed Date:  2012-11-07     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  S119-26     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell-Free System
DNA / analysis*
Female
Great Britain
Humans
Male
Prenatal Diagnosis*
Sex Determination Analysis*
Grant Support
ID/Acronym/Agency:
RP-PG-0707-10107//Department of Health
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Diverse and highly active diazotrophic assemblages inhabit ephemerally wetted soils of the Antarctic...
Next Document:  The shape effect on nanoparticle solvation: A comparison of morphometric thermodynamics and microsco...