Document Detail


Implementing a ketogenic diet based on medium-chain triglyceride oil in pediatric patients with cancer.
MedLine Citation:
PMID:  7759747     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Traditionally, a ketogenic diet is given to drug-resistant children with epilepsy to improve seizure control. Inducing a ketogenic state in patients with cancer may be a useful adjunct to cancer treatment by affecting tumor glucose metabolism and growth while maintaining the patient's nutritional status. A ketogenic diet consisting of 60% medium-chain triglyceride (MCT) oil, 20% protein, 10% carbohydrate, and 10% other dietary fats was provided to a select group of pediatric patients with advanced-stage cancer to test the effects of dietary-induced ketosis on tumor glucose metabolism. Issues of tolerance and compliance for patients consuming an oral diet (consisting of normal table foods and daily MCT oil "shakes") and for patients receiving an enteral formula are reviewed. Preliminary use of the MCT oil-based diet suggests a potential in pediatric patients with cancer.
Authors:
L C Nebeling; E Lerner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  95     ISSN:  0002-8223     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-06-28     Completed Date:  1995-06-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  693-7     Citation Subset:  AIM; IM    
Affiliation:
Nutrition Department, Case Western Reserve University, Cleveland, Ohio 44106-4906, USA.
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MeSH Terms
Descriptor/Qualifier:
Child
Combined Modality Therapy
Dietary Fats / administration & dosage,  adverse effects,  therapeutic use*
Enteral Nutrition
Epilepsy / diet therapy
Food, Formulated*
Humans
Ketosis / etiology*
Minerals / administration & dosage
Neoplasms / diet therapy*,  therapy
Patient Compliance
Triglycerides / administration & dosage,  adverse effects,  therapeutic use*
Vitamins / administration & dosage
Grant Support
ID/Acronym/Agency:
M01 RR00080-29/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Minerals; 0/Triglycerides; 0/Vitamins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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