Document Detail

Implantation markers and endometriosis.
MedLine Citation:
PMID:  16274610     Owner:  NLM     Status:  MEDLINE    
The receptive phase of the endometrium seems to occur in close association with the appearance of pinopodes and endometrial integrins that may be activated by the interleukin-1 system (IL-1). Embryo attachment is the result of adhesion protein expression, and the invasion of the embryo is governed by proteolytic enzymes. Leukaemia inhibitory factor (LIF) is produced by natural killer lymphocytes that interact with the invading trophoblast. This may activate urokinase plasminogen activator (uPA) and gelatinase enzymes, which play a crucial role in trophoblast invasion. Oestrogen stimulates, while progesterone inhibits, LIF. The role of endometrial contractility in displacing human embryos from the Fallopian tube to the lumen cavity of the uterus or vagina in terms of pregnancy or wastage is still a matter of discussion. Endometriosis and its associated abnormal uterine contractions may be also linked to implantation failure. Unless new evidence emerges to indicate otherwise, it can be assumed that progesterone is, either in a direct (non-genomic: contractility) or indirect (genomic: decidualization) manner, the only determinant of endometrial priming necessary for embryo nidation.
Carlo Bulletti; Carlo Flamigni; Dominique de Ziegler
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  11     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-11-08     Completed Date:  2006-02-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  464-8     Citation Subset:  IM    
Physiopathology of Reproduction, AUSL di Rimini and University of Bologna, Via Settembrini 2, 47900 Rimini, Italy.
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MeSH Terms
Biological Markers / metabolism
Embryo Implantation*
Endometriosis / complications,  diagnosis*,  metabolism
Endometrium / pathology
Estrogens / metabolism
Hormones / metabolism
Infertility, Female
Interleukin-1 / metabolism*
Interleukin-6 / metabolism
Killer Cells, Natural / metabolism
Leukemia Inhibitory Factor
Lymphocytes / metabolism
Models, Biological
Urokinase-Type Plasminogen Activator / metabolism
Uterine Contraction
Reg. No./Substance:
0/Biological Markers; 0/Estrogens; 0/Hormones; 0/Interleukin-1; 0/Interleukin-6; 0/LIF protein, human; 0/Leukemia Inhibitory Factor; EC Plasminogen Activator

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