| Implantation markers and endometriosis. | |
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MedLine Citation:
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PMID: 16274610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The receptive phase of the endometrium seems to occur in close association with the appearance of pinopodes and endometrial integrins that may be activated by the interleukin-1 system (IL-1). Embryo attachment is the result of adhesion protein expression, and the invasion of the embryo is governed by proteolytic enzymes. Leukaemia inhibitory factor (LIF) is produced by natural killer lymphocytes that interact with the invading trophoblast. This may activate urokinase plasminogen activator (uPA) and gelatinase enzymes, which play a crucial role in trophoblast invasion. Oestrogen stimulates, while progesterone inhibits, LIF. The role of endometrial contractility in displacing human embryos from the Fallopian tube to the lumen cavity of the uterus or vagina in terms of pregnancy or wastage is still a matter of discussion. Endometriosis and its associated abnormal uterine contractions may be also linked to implantation failure. Unless new evidence emerges to indicate otherwise, it can be assumed that progesterone is, either in a direct (non-genomic: contractility) or indirect (genomic: decidualization) manner, the only determinant of endometrial priming necessary for embryo nidation. |
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Authors:
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Carlo Bulletti; Carlo Flamigni; Dominique de Ziegler |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 11 ISSN: 1472-6483 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-11-08 Completed Date: 2006-02-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 464-8 Citation Subset: IM |
Affiliation:
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Physiopathology of Reproduction, AUSL di Rimini and University of Bologna, Via Settembrini 2, 47900 Rimini, Italy. bulletticarlo@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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metabolism Embryo Implantation* Endometriosis / complications, diagnosis*, metabolism Endometrium / pathology Estrogens / metabolism Female Fertilization Hormones / metabolism Humans Infertility, Female Interleukin-1 / metabolism* Interleukin-6 / metabolism Killer Cells, Natural / metabolism Leukemia Inhibitory Factor Lymphocytes / metabolism Models, Biological Ovulation Pregnancy Urokinase-Type Plasminogen Activator / metabolism Uterine Contraction |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Estrogens; 0/Hormones; 0/Interleukin-1; 0/Interleukin-6; 0/LIF protein, human; 0/Leukemia Inhibitory Factor; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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