Document Detail


Implantation of episcleral electrodes via anterior orbitotomy for stimulation of the retina with induced photoreceptor degeneration: an in vivo feasibility study on a conceptual visual prosthesis.
MedLine Citation:
PMID:  18385925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A visual prosthesis is a conceptual device designed to harnesses the function of residual afferent neurons in the visual pathway to produce artificial vision. Such implant, when applied to stimulate the vitreous surface of the retina, has proven feasible in producing the perception of light in both animals and humans. However the practicality of such device has been challenged by the difficulty of surgical access and the risks of damaging the neuroretina. Positioning a visual implant over the scleral surface of the eye could present a safer alternative but this stimulation modality has not been tested in diseased retinas and little is known about the altered electrophysiological properties of the retina in influencing the feasibility of such approach. METHODS: Experimental photoreceptor degeneration was induced in four pigmented rabbit eyes with systematic administration of a retinotoxic agent, sodium iodate. A multielectrode array was implanted onto the surface of the sclera to target the central and peripheral parts of the retina via an anterior orbitotomy approach. The efficacy of retinal stimulation was assessed by recording electrical evoked potential over the primary visual cortex. FINDINGS: The electrical evoked potentials were obtained from both injected and control eyes. The charge density thresholds were found to be similar in both groups and were below the bioelectric safety limit. Spatially differentiated cortical activation profiles were obtained from the central and peripheral retina and the pattern of activation corresponded to the retinotopography of the rabbit primary visual cortex. CONCLUSION: This study proves that episcleral stimulation of the retina is a feasible alternative to intraocular approaches for the development of a visual prosthesis for retinas with photoreceptor loss.
Authors:
T Siu; J Morley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-03
Journal Detail:
Title:  Acta neurochirurgica     Volume:  150     ISSN:  0942-0940     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-06-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  477-85; discussion 485     Citation Subset:  IM    
Affiliation:
School of Medical Sciences, University of New South Wales, Sydney, Australia. siloti@tpg.com.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Electric Stimulation Therapy / instrumentation,  methods*
Electrodes, Implanted*
Electroretinography
Equipment Design
Evoked Potentials
Feasibility Studies
Orbit / surgery*
Photoreceptor Cells, Vertebrate*
Rabbits
Reaction Time
Retina / physiopathology*
Retinal Degeneration / diagnosis,  physiopathology,  therapy*
Sclera
Visual Cortex / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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