Document Detail

Implantation of decellularized small-caliber vascular xenografts with and without surface heparin treatment.
MedLine Citation:
PMID:  17298398     Owner:  NLM     Status:  MEDLINE    
Heparin treatment of decellularized xenografts has been reported to reduce graft thrombogenicity. However, little is known about the in vivo comparison of heparin-treated with non-heparin-treated xenografts, especially for small-caliber vascular implants. We implanted either a heparin-treated or a non-heparin-treated canine carotid artery as bilateral carotid xenograft in rabbits (n = 24). Small-caliber xenografts (3 approximately 4 mm) were decellularized by enzymatic and detergent extraction and were further covalently linked with heparin. During implantation, thrombosis rate was 4% in the heparin-treated xenografts and 25% in the non-heparin-treated xenografts after 3 weeks (P < 0.05). After 6 months, it was 8 versus 58%, respectively (P < 0.01). Both heparin-treated and non-heparin-treated xenografts harvested at the end of 3 and 6 months showed a satisfactory cellular reconstruction of either smooth muscle cells or endothelial cells. These results indicate that heparin treatment of the small-caliber decellularized xenograft reduces the in vivo thrombogenicity. Both heparin-treated and non-heparin-treated xenografts seem to undergo a similar cellular remodeling process up to 6 months.
Xue-Ning Wang; Chang-Zhi Chen; Min Yang; Y John Gu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  31     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-14     Completed Date:  2007-04-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-104     Citation Subset:  IM    
Department of Cardiothoracic Surgery, Renji Hospital, Shanghai Jiaotong University Medical College, Shanghai, China.
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MeSH Terms
Anticoagulants / administration & dosage*
Carotid Artery, Common / transplantation*
Endothelium, Vascular
Heparin / administration & dosage*
Models, Animal
Thrombosis / prevention & control
Transplantation, Heterologous / immunology,  methods*
Ultrasonography, Doppler, Duplex
Vascular Patency / drug effects*
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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