Document Detail

Impending fractures in giant cell tumours of the distal femur: incidence and outcome.
MedLine Citation:
PMID:  16474936     Owner:  NLM     Status:  MEDLINE    
Giant cell tumours are rare bone tumours that are characteristically benign but locally aggressive, most frequently occurring in the distal femur with pathological fractures being common. This paper investigates relationships between tumour size and cortical breach on initial X-rays and subsequent treatment. The X-rays of 54 patients with distal femoral giant cell tumours were reviewed. The volumes of the tumour, distal femur and a ratio between the two parameters were estimated. The presence of a cortical breach, discrete fracture and Campanacci grade was recorded. X-rays revealed intact cortical rim in 20 patients (37%), cortical breach in 22 patients (41%) and discrete fracture in 12 patients (22%). There was a significant difference in the ratio of tumour volume to distal femoral volume between the discrete fracture group and the cortical breach group. No significant differences in rates of local recurrence were demonstrated. Extended curettage was effective for intact and cortical breach groups; however, patients in the fracture group often required radical treatment.
L M Jeys; R Suneja; G Chami; R J Grimer; S R Carter; R M Tillman
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Publication Detail:
Type:  Journal Article     Date:  2006-02-11
Journal Detail:
Title:  International orthopaedics     Volume:  30     ISSN:  0341-2695     ISO Abbreviation:  Int Orthop     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-24     Completed Date:  2006-09-28     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7705431     Medline TA:  Int Orthop     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  135-8     Citation Subset:  IM    
Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Northfield, Birmingham, B31 2AP, UK.
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MeSH Terms
Analysis of Variance
Femoral Fractures / epidemiology*,  physiopathology*,  radiography
Femoral Neoplasms / physiopathology*,  radiography
Giant Cell Tumor of Bone / physiopathology*,  radiography
Middle Aged
Neoplasm Recurrence, Local
Prospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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