| Impedance measurement during air and helium-oxygen breathing before and after salbutamol in COPD patients. | |
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MedLine Citation:
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PMID: 1555329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The forced oscillation technique is an effort-independent method used to characterize the mechanical impedance of the respiratory system. To support the hypothesis that non-invasive partitioning of total pulmonary resistance is possible by this technique, impedance was measured during air breathing and after equilibration with a mixture of 80% helium (He) and 20% oxygen (O2) in 21 chronic obstructive pulmonary disease (COPD) patients by means of a forced pseudo-random noise pressure signal over a frequency spectrum from 4 to 52 Hz. Furthermore, during inhalation of both gas mixtures impedance was determined before and after inhalation of 0.400 mg Salbutamol. 2. He + O2 breathing caused less negative frequency dependence of resistance and a significant decrease in reactance over the range 16-52 Hz. Inhalation of Salbutamol caused a marked increase in reactance values over the range 8-40 Hz. However after equilibration with the He + O2 mixture, Salbutamol caused a significant decrease in resistance and a significant increase in reactance at all frequencies. 3. The results during He + O2 breathing are in accordance with a partitioning of airways resistance into central and peripheral components. The decrease in reactance during He + O2 can be explained by a density dependent decrease in inductive reactance. By comparing the impedance data during air and He + O2 breathing, it can be concluded that a distribution of pulmonary resistance with minimal losses in the larger airways is more sensitive for detecting changes in the peripheral airways in COPD patients. |
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Authors:
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E F Wouters; F J Lándsér; A H Polko; B F Visser |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 19 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-05-04 Completed Date: 1992-05-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 95-101 Citation Subset: IM |
Affiliation:
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Department of Pulmonary Diseases, University Limburg, Maastricht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Airway Resistance / drug effects* Albuterol / pharmacology* Female Helium Humans Lung Compliance Lung Diseases, Obstructive / physiopathology* Male Middle Aged Oxygen |
| Chemical | |
Reg. No./Substance:
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18559-94-9/Albuterol; 7440-59-7/Helium; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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