Document Detail


Impedance cardiography in the diagnosis of capillary leak syndrome caused by doxorubicin therapy in a patient with myeloma multiplex.
MedLine Citation:
PMID:  20104463     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytotoxicity of drugs can be a cause of cardiorespiratory disorders connected with chemotherapy. Doxorubicin is an antibiotic from the group of anthracyclines effective in antineoplastic therapy of solid and hematopoetic tumors. The most common cause of therapy ceasing is its cardiotoxicity. However, a lung injury connected with its cytotoxic activity to pulmonary endothelium (capillary leak syndrome) can be an equally serious complication. In the case presented, rapid, multi-profile diagnostics with the use of impedance cardiography, a modern noninvasive tool of hemodynamic monitoring, led to the recognition and effective treatment of a rare clinical syndrome.
Authors:
Pawe? Krzesi?ski; Robert Wierzbowski; Grzegorz Gielerak; Janusz Ha?ka; Oxana Matysiak; Pawe? Smurzy?ski
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cardiology journal     Volume:  17     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  88-91     Citation Subset:  IM    
Affiliation:
Department of Cardiology and Internal Diseases, Military Institute of the Health Services, Warszawa, Poland. pakrzesinski@interia.pl
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MeSH Terms
Descriptor/Qualifier:
Aged
Antibiotics, Antineoplastic / adverse effects*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Capillary Leak Syndrome / chemically induced*,  diagnosis*
Cardiography, Impedance*
Cyclophosphamide / therapeutic use
Doxorubicin / adverse effects*
Humans
Lung / blood supply*
Male
Melphalan / therapeutic use
Multiple Myeloma / drug therapy*
Prednisone / therapeutic use
Retreatment
Treatment Outcome
Vincristine / therapeutic use
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/VMCP protocol; 148-82-3/Melphalan; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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