Document Detail


Impairments of speech fluency in Lewy body spectrum disorder.
MedLine Citation:
PMID:  22099969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Few studies have examined connected speech in demented and non-demented patients with Parkinson's disease (PD). We assessed the speech production of 35 patients with Lewy body spectrum disorder (LBSD), including non-demented PD patients, patients with PD dementia (PDD), and patients with dementia with Lewy bodies (DLB), in a semi-structured narrative speech sample in order to characterize impairments of speech fluency and to determine the factors contributing to reduced speech fluency in these patients. Both demented and non-demented PD patients exhibited reduced speech fluency, characterized by reduced overall speech rate and long pauses between sentences. Reduced speech rate in LBSD correlated with measures of between-utterance pauses, executive functioning, and grammatical comprehension. Regression analyses related non-fluent speech, grammatical difficulty, and executive difficulty to atrophy in frontal brain regions. These findings indicate that multiple factors contribute to slowed speech in LBSD, and this is mediated in part by disease in frontal brain regions.
Authors:
Sharon Ash; Corey McMillan; Rachel G Gross; Philip Cook; Delani Gunawardena; Brianna Morgan; Ashley Boller; Andrew Siderowf; Murray Grossman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-11-17
Journal Detail:
Title:  Brain and language     Volume:  120     ISSN:  1090-2155     ISO Abbreviation:  Brain Lang     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-07-03     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  7506220     Medline TA:  Brain Lang     Country:  United States    
Other Details:
Languages:  eng     Pagination:  290-302     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Corpus Striatum / physiopathology
Female
Humans
Lewy Body Disease / complications,  physiopathology*
Linguistics
Male
Middle Aged
Narration
Neuropsychological Tests
Parkinson Disease / complications,  physiopathology*
Prefrontal Cortex / physiopathology*
Speech / physiology*
Speech Disorders / diagnosis,  etiology,  physiopathology*
Speech Production Measurement
Grant Support
ID/Acronym/Agency:
AG15116/AG/NIA NIH HHS; AG17586/AG/NIA NIH HHS; AG32953/AG/NIA NIH HHS; NS44266/NS/NINDS NIH HHS; NS53488/NS/NINDS NIH HHS; P01 AG017586/AG/NIA NIH HHS; P01 AG032953/AG/NIA NIH HHS; P50 NS053488/NS/NINDS NIH HHS; R01 AG015116/AG/NIA NIH HHS; R01 AG015116-12/AG/NIA NIH HHS; R01 NS044266/NS/NINDS NIH HHS; R01 NS044266-05/NS/NINDS NIH HHS
Comments/Corrections

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