Document Detail


Impairment of vitamin D and bone metabolism in patients with bypass operation for obesity.
MedLine Citation:
PMID:  284717     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-four patients were studied 2--6 years after jejunoileal bypass for morbid obesity. The serum concentration of 25-hydroxyvitamin D (25-OHD) were reduced and related to the frequency fo stools and to the weight reduction. Fifteen patients were not able to normalize serum 25-OHD following a long-term regular vitamin D intake. The serum immunoreactive parathyroid hormone concentration (iPTH) and the alkaline phosphatase levels were elevated in this group, indicating a secondary hyperparathyroidism. The mean bone mineral content of the forearm was reduced 3--6 years after the operation, most severely in those with elevated serum iPTH. The desired weight reduction by jejunoileal shunt was obtained at the expense of a severely disturbed vitamin D metabolism. We suggest, that all patients with an intestinal bypass for obesity should receive regular vitamin D supplement, and serum 25-OHD should be measured in order to monitor the effect of therapy.
Authors:
H Hey; B Lund; O H Sørensen; B Lund; M S Christensen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica. Supplementum     Volume:  624     ISSN:  0365-463X     ISO Abbreviation:  Acta Med. Scand. Suppl.     Publication Date:  1979  
Date Detail:
Created Date:  1979-05-23     Completed Date:  1979-05-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370331     Medline TA:  Acta Med Scand Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  73-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alkaline Phosphatase / blood
Body Weight
Bone and Bones / metabolism*
Calcium / metabolism
Humans
Hydroxycholecalciferols / blood
Hyperparathyroidism, Secondary / etiology
Intestine, Small / surgery*
Middle Aged
Obesity / metabolism,  therapy*
Parathyroid Hormone / blood
Phosphates / blood
Postoperative Complications
Vitamin D / administration & dosage
Vitamin D Deficiency / blood,  etiology*
Chemical
Reg. No./Substance:
0/Hydroxycholecalciferols; 0/Parathyroid Hormone; 0/Phosphates; 1406-16-2/Vitamin D; 7440-70-2/Calcium; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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