Document Detail

Impairment of vasomotor reflexes in the fingertips of leprosy patients.
MedLine Citation:
PMID:  1800668     Owner:  NLM     Status:  MEDLINE    
A method is described for eliciting fingertip vasomotor reflexes by inspiratory gasp and contralateral hand cold challenge. The results of the two tests are reproducible on replicate testing and, when taken together, have proved reliable for detection of impairment of autonomic reflexes in 10 newly registered leprosy patients who did not have any obvious deformity. Similar, but less severe, impairment of vasomotor reflexes was noted in a group of 10 fully treated, apparently cured ex-leprosy patients, none of whom showed clinically obvious neuropathy. Both the new patients and the ex-patients were significantly different from healthy contacts and from healthy Europeans, who were indistinguishable by this test. Evidence is presented suggesting that impairment of these vasomotor reflexes is mainly due to damage to the efferent pathway in the peripheral nerves. The method might prove valuable for investigation of early nerve damage in new patients or during reversal reactions in leprosy at a stage before irreversible damage is done.
J S Beck; N C Abbot; P D Samson; C R Butlin; J M Grange; I A Cree; A Forster; F Khan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  54     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-04-21     Completed Date:  1992-04-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  965-71     Citation Subset:  IM    
Department of Pathology, University of Dundee, UK.
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MeSH Terms
Autonomic Nervous System / physiopathology
Discriminant Analysis
Fingers / blood supply*
Leprosy / physiopathology*
Middle Aged
Peripheral Nerves / physiopathology
Reflex, Abnormal / physiology*
Regional Blood Flow / physiology
Vasomotor System / physiopathology*

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