Document Detail

Impairment of sympathetic pulmonary vasoconstriction by 3-methylindole in cattle.
MedLine Citation:
PMID:  4014839     Owner:  NLM     Status:  MEDLINE    
Sixteen Holstein cattle allotted into 4 groups (4 cattle/group) were each given a single oral dosage of 0.2 g of 3-methylindole (3MI)/kg of body weight. The groups were killed at 12, 24, 48, and 72 hours, respectively, after 3MI administration. Comparison of clinical signs, pathologic pulmonary lesions, and in vitro pulmonary artery responses to pharmacologic stimuli was made between the 4 treated groups and 8 control Holstein cattle of similar age. Clinical signs of pulmonary distress first appeared 8 to 12 hours after 3MI administration. After 20 hours, clinical signs included dyspnea, moderate depression, and a marked expiratory grunt. A partial remission of these clinical signs was seen between 30 and 45 hours after 3MI administration. After remission, the cattle had clinical signs of severe dyspnea and depression and expiratory grunts were more pronounced. Pathologic pulmonary lesions, including heavy rubbery lungs, dilated interlobular septae, and subplural air bullae characteristic of pulmonary edema and interstitial emphysema were observed. The lungs of treated cattle did not collapse when the thorax was incised at necropsy. In vitro pulmonary artery strips contracted dose dependently to norepinephrine (NE). Group I tissues (12 hours after 3MI administration) responded similarly to control samples. Group II tissues (24 hours after 3MI administration) had a significant inhibition (P less than 0.05) in response to NE stimulation as compared with controls.
M S Perry; O S Atwal; P Eyre
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  46     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-08-05     Completed Date:  1985-08-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  905-8     Citation Subset:  IM    
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MeSH Terms
Cattle / physiology*
Cattle Diseases / chemically induced
Indoles / toxicity*
Lung / blood supply,  drug effects*,  pathology
Pulmonary Artery / drug effects*
Pulmonary Edema / chemically induced,  veterinary
Pulmonary Emphysema / chemically induced,  veterinary
Skatole / toxicity*
Vasoconstriction / drug effects*
Reg. No./Substance:
0/Indoles; 83-34-1/Skatole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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