| Impairment of skin microvascular reactivity in hypertension and uraemia. | |
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MedLine Citation:
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PMID: 15985514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Uraemia and hypertension are associated with higher risk for cardiovascular complications. Endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases. The aim of the present study was to evaluate endothelial function in the forearm skin microcirculation of patients with essential hypertension, in hypertensive haemodialysis patients and in normotensive control subjects. METHODS: We performed laser Doppler flowmetry with iontophoresis of acetylcholine (ACh) and of sodium nitroprusside (SNP) as well as the post-occlusive reactive hyperaemia test (PORH) in 16 normal control subjects (CONT), in 16 patients with essential hypertension (EHT) and in 16 haemodialysis patients with essential hypertension (DHT). Plasma levels of endothelin-1, big-endothelin and von Willebrand factor (vWF) were also measured. RESULTS: The average hyperaemic response to the higher dose of ACh iontophoresis was 801+/-110% in CONT, 563+/-69 % in EHT and 308+/-64% in DHT (P<0.05, between all comparisons). Vasodilation to the higher dose of SNP was 791+/-79% in CONT, 633+/-72% in EHT and 355+/-69% in DHT (NS, P<0.001 compared with controls, respectively). The average peak flow during PORH was significantly lower in both the EHT and DHT groups compared with controls (294+/-39, 267+/-59 and 429+/-45%, respectively, P<0.05). Levels of endothelin-1, big endothelin, vWF and vWF activity were significantly higher in the DHT group (P<0.05, compared with controls). CONCLUSIONS: In hypertensive haemodialysis patients, both endothelium-dependent and -independent vasodilation was impaired. The observed increase in plasma markers of endothelial damage indicated a progression of vascular disease. |
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Authors:
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Katalin Farkas; János Nemcsik; Endre Kolossváry; Zoltán Járai; Eva Nádory; Csaba Farsang; István Kiss |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-06-28 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 20 ISSN: 0931-0509 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-10 Completed Date: 2006-01-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 1821-7 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, St Imre Teaching Hospital, Tétényi u.12-16. Budapest, 1115 Hungary. katalin.farkas@sztimrehosp.hu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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therapeutic use Antihypertensive Agents / classification, therapeutic use Diuretics / therapeutic use Female Humans Hypertension / complications, drug therapy*, physiopathology* Laser-Doppler Flowmetry Male Microcirculation / physiopathology* Middle Aged Renal Dialysis / adverse effects Skin / blood supply* Uremia / complications, physiopathology* Vascular Diseases / etiology* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Diuretics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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