Document Detail

Impairment of sarcolemmal permeability in the acute ischemic myocardium--a study with ionic lanthanum probe method.
MedLine Citation:
PMID:  1404846     Owner:  NLM     Status:  MEDLINE    
Impairment of sarcolemmal permeability after the initiation of acute ischemic myocardial injury was studied using an ionic lanthanum (La3+) probe in electron microscopy. Acute ischemic myocardium was induced by ligation of the left anterior descending coronary artery in dogs. In normal cardiac myocytes La is localized exclusively in the extracellular space. i.e. on the glycocalyx, in the T-system and in intercalated discs, with normal fine structures. In ischemic myocardial cells, La deposits were found in the cytosolic space in 22% of subendocardial cells with mild to moderate, but non-necrotic, fine structural changes as early as 30 min. The number of myocytes with La deposition increased with advancing ischemic injury, and necrotic fine structural changes were recognized following ischemia for 60 min. These results indicate that deposition of La occurs before the appearance of irreversible morphologic alterations in ischemic myocardial cells, and suggest an increased permeability of the sarcolemma for Ca2+ and the development of degradation of plasma membrane integrity.
F Tanno; K Akiyama; E Geshi; T Yanagishita; N Konno; T Katagiri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese circulation journal     Volume:  56     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-13     Completed Date:  1992-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  911-20     Citation Subset:  IM    
Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
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MeSH Terms
Calcium / metabolism
Extracellular Space / metabolism
Lanthanum / diagnostic use*,  pharmacokinetics
Microscopy, Electron
Myocardial Ischemia / metabolism*,  pathology
Myocardium / metabolism*,  ultrastructure
Sarcolemma / metabolism*,  ultrastructure
Reg. No./Substance:
7439-91-0/Lanthanum; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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