Document Detail


Impairment of odor recognition and odor-induced emotions in type 1 myotonic dystrophy.
MedLine Citation:
PMID:  21884754     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study aimed to test whether type 1 myotonic dystrophy (DM1) patients who have a lower sensitivity to emotional facial expressions have an abnormal olfactory threshold or recognition level. We measured DM1 patients' performances in an olfactory acuity test and respiratory responses to odor stimuli, and compared their results to those of healthy controls (HCs). We found that DM1 patients exhibited a significantly reduced odor detection sensitivity compared with that in HCs. Three out of seven DM1 patients exhibited impaired odor recognition, while other four patients had significantly lower odor recognition compared with HCs. Even when patients were able to identify the type of odor, the levels of pleasantness they reported experiencing in response to a pleasant odor were significantly lower than those reported by HCs. These subjective data in DM1 patients were reflected in the respiratory responses (RRs). In the current study, one patient showed impairments in both odor detection and odor recognition. Abnormalities of the olfactory limbic areas might have been the cause of the olfactory impairments observed in the DM1 patients.
Authors:
Yuri Masaoka; Mitsuru Kawamura; Akitoshi Takeda; Mutsutaka Kobayakawa; Takeshi Kuroda; Hideyo Kasai; Natsuko Tsuruya; Akinori Futamura; Ikuo Homma
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-22
Journal Detail:
Title:  Neuroscience letters     Volume:  -     ISSN:  1872-7972     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ireland Ltd.
Affiliation:
Department of Physiology II, Showa University School of Medicine, Japan.
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