Document Detail

Impairment of muscle energy metabolism in patients with sleep apnoea syndrome.
MedLine Citation:
PMID:  9415356     Owner:  NLM     Status:  MEDLINE    
Impairment of muscle energy metabolism has been demonstrated in normal subjects with chronic hypoxaemia (altitude chronic respiratory failure). The purpose of this study was to verify the hypothesis that a comparable condition could develop in patients with sleep apnoea syndrome (SAS), considering that they are exposed to prolonged and repeated hypoxaemia periods. Muscle metabolism was assessed in 11 patients with SAS performing a maximal effort on cycloergometer. In comparison with normal subjects, SAS patients reached lower maximal loads [144 +/- 7 vs. 182 +/- 10 W (P < 0.005)] and lower peak oxygen uptakes [26.4 +/- 1.2 vs 33.2 +/- 1.4 ml kg-1 min-1 (P < 0.005)]. Abnormal metabolic features were found: maximal blood lactate concentration was significantly lower than in normal subjects [0.034 +/- 0.004 vs. 0.044 +/- 0.002 mmol l-1 W-1 (P < 0.05)]; and lactate elimination rate, calculated during a 30-min recovery period, was reduced [0.127 +/- 0.017 vs, 0.175 +/- 0.014 mmol l-1 min-1 (P < 0.025)]. The extent of these anomalies correlated with the severity of SAS. The patients also showed higher maximal diastolic blood pressures than normal subjects [104 +/- 5 vs. 92 +/- 4 mmHg (P < 0.05)]. These results can be interpreted as indications of an impairment of muscle energy metabolism in patients with SAS. Decrease in maximum blood lactate concentration suggests an impairment of glycolytic metabolism, while decrease in the rate of lactate elimination indicates a defect in oxidative metabolism. Since no respiratory pathology apart from SAS was found in this group of patients, it seems legitimate to link the genesis of these impairments to repeated bouts of nocturnal hypoxaemia.
D Vanuxem; M Badier; C Guillot; S Delpierre; F Jahjah; P Vanuxem
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiratory medicine     Volume:  91     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-01-29     Completed Date:  1998-01-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  551-7     Citation Subset:  IM    
Laboratoire d'Exploration de la Fonction Respiratoire et du Métabolisme Musculaire, Hôpital Sainte Marguerite, Marseille, France.
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MeSH Terms
Ammonia / blood
Blood Pressure
Case-Control Studies
Energy Metabolism*
Exercise Test
Heart Rate
Lactic Acid / blood
Lung / physiopathology
Metabolic Clearance Rate
Middle Aged
Muscle, Skeletal / metabolism*
Regression Analysis
Respiratory Function Tests
Sleep Apnea Syndromes / metabolism*,  physiopathology
Reg. No./Substance:
50-21-5/Lactic Acid; 7664-41-7/Ammonia

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