| Impairment of leukocyte deformability in patients undergoing esophagectomy. | |
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MedLine Citation:
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PMID: 19252235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impaired deformability might contribute to the accumulation of activated leukocytes within pulmonary microcapillaries, leading to acute lung injury. The purpose of our study was to investigate changes in leukocyte deformability during periods of inflammation after esophagectomy. The study group comprised 20 patients who underwent esophagectomy. Changes in leukocyte deformability were investigated by examining filtration through a silicon microchannel, which simulated human pulmonary microcapillaries. Changes in the neutrophil cytoskeleton were investigated by measuring neutrophil F-actin assembly. The severity of patient clinical outcome was evaluated by the lung injury score. Leukocyte filtration through the microchannel was significantly weaker in esophagectomy patients than in healthy subjects (p<0.01). After esophagectomy, filtration was further impaired compared with preoperative values (p<0.05). The neutrophil F-actin content was higher in patients than in controls (p<0.01), and increased after esophagectomy compared with preoperative values (p<0.01). We concluded that circulating leukocytes showed reduced deformability and appeared to be sequestered within microcapillaries after esophagectomy. Changes in neutrophil cytoskeleton were considered to be responsible for the reduced deformability. Leukocyte accumulation within pulmonary microcapillaries might be related to the pathogenesis of lung injury after esophagectomy. |
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Authors:
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Tomohiko Suemori; Hiroshi Morimatsu; Satoshi Mizobuchi; Kiyoshi Morita; Yuki Katanosaka; Satoshi Mohri; Keiji Naruse |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical hemorheology and microcirculation Volume: 41 ISSN: 1386-0291 ISO Abbreviation: Clin. Hemorheol. Microcirc. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-03-02 Completed Date: 2009-06-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709206 Medline TA: Clin Hemorheol Microcirc Country: Netherlands |
Other Details:
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Languages: eng Pagination: 127-36 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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immunology*,
physiopathology Case-Control Studies Esophagectomy / adverse effects* Female Flow Cytometry Hemorheology / immunology Humans Inflammation / physiopathology Male Microcirculation / immunology Microfluidic Analytical Techniques Neutrophils / physiology*, ultrastructure Postoperative Complications / immunology* Pulmonary Circulation / immunology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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