Document Detail

Impairment of leukocyte deformability in patients undergoing esophagectomy.
MedLine Citation:
PMID:  19252235     Owner:  NLM     Status:  MEDLINE    
Impaired deformability might contribute to the accumulation of activated leukocytes within pulmonary microcapillaries, leading to acute lung injury. The purpose of our study was to investigate changes in leukocyte deformability during periods of inflammation after esophagectomy. The study group comprised 20 patients who underwent esophagectomy. Changes in leukocyte deformability were investigated by examining filtration through a silicon microchannel, which simulated human pulmonary microcapillaries. Changes in the neutrophil cytoskeleton were investigated by measuring neutrophil F-actin assembly. The severity of patient clinical outcome was evaluated by the lung injury score. Leukocyte filtration through the microchannel was significantly weaker in esophagectomy patients than in healthy subjects (p<0.01). After esophagectomy, filtration was further impaired compared with preoperative values (p<0.05). The neutrophil F-actin content was higher in patients than in controls (p<0.01), and increased after esophagectomy compared with preoperative values (p<0.01). We concluded that circulating leukocytes showed reduced deformability and appeared to be sequestered within microcapillaries after esophagectomy. Changes in neutrophil cytoskeleton were considered to be responsible for the reduced deformability. Leukocyte accumulation within pulmonary microcapillaries might be related to the pathogenesis of lung injury after esophagectomy.
Tomohiko Suemori; Hiroshi Morimatsu; Satoshi Mizobuchi; Kiyoshi Morita; Yuki Katanosaka; Satoshi Mohri; Keiji Naruse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  41     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2009  
Date Detail:
Created Date:  2009-03-02     Completed Date:  2009-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  127-36     Citation Subset:  IM    
Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
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MeSH Terms
Acute Lung Injury / immunology*,  physiopathology
Case-Control Studies
Esophagectomy / adverse effects*
Flow Cytometry
Hemorheology / immunology
Inflammation / physiopathology
Microcirculation / immunology
Microfluidic Analytical Techniques
Neutrophils / physiology*,  ultrastructure
Postoperative Complications / immunology*
Pulmonary Circulation / immunology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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