Document Detail

Impairment of the left ventricular systolic and diastolic function in patients with non-alcoholic fatty liver disease.
MedLine Citation:
PMID:  20865675     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is considered the liver component of the metabolic syndrome. We investigated the diastolic and systolic functional parameters of patients with NAFLD and the impact of metabolic syndrome on these parameters.
METHODS: Thirty-five non-diabetic, normotensive NAFLD patients, and 30 controls, were included in this study. Each patient underwent transthoracic conventional and tissue Doppler echocardiography (TDI) for the assessment of left ventricular (LV) diastolic and systolic function. Study patients were also evaluated with 24-hour ambulatory blood pressure monitoring.
RESULTS: NAFLD patients had higher blood pressures, increased body mass indices, and more insulin resistance than controls. TDI early diastolic velocity (E' on TDI) values were lower in NAFLD patients than the controls (11.1 ± 2.1 vs 15.3 ± 2.7; p < 0.001). TDI systolic velocity (S' on TDI) values were lower in NAFLD patients than the controls (9.34 ± 1.79 vs 10.6 ± 1.52; p = 0.004). E' on TDI and S' on TDI values were moderately correlated with night-systolic blood pressure, night-diastolic blood pressure, and night-mean blood pressure in NAFLD patients.
CONCLUSIONS: Patients with NAFLD have impaired LV systolic and diastolic function even in the absence of morbid obesity, hypertension, or diabetes.
Hakan Fotbolcu; Tolga Yakar; Dursun Duman; Tansu Karaahmet; Kursat Tigen; Cihan Cevik; Unal Kurtoglu; Ismet Dindar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology journal     Volume:  17     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-24     Completed Date:  2011-01-19     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  457-63     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / physiology
Blood Pressure Monitoring, Ambulatory
Diastole / physiology
Echocardiography, Doppler*
Fatty Liver / epidemiology
Middle Aged
Systole / physiology
Ventricular Dysfunction, Left / epidemiology*,  physiopathology,  ultrasonography*

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