Document Detail

Impairment of left ventricular function in systemic lupus erythematosus evaluated by measuring myocardial performance index with tissue Doppler echocardiography.
MedLine Citation:
PMID:  15839986     Owner:  NLM     Status:  MEDLINE    
In 44 patients affected by systemic lupus erythematosus (SLE) without any clinical signs of heart disease (group I) the myocardial performance index (MPI) was calculated to investigate left ventricular function. The index, as the sum of isovolumetric contraction time (ICT) and isovolumetric relaxation time (IRT) divided by ejection time (ET), was measured by tissue Doppler echocardiography (TDE). Results achieved show a prolonged MPI with respect to the values recorded in healthy controls (group II). Its prolongation is due to a significant increase of IRT, whereas ICT and ET were within the normal limits. In patients with SLE without an evident cardiac engagement, this outcome seems to depend on a prevalent diastolic left ventricular dysfunction, perhaps due to a subclinical myocarditis. TDE is more precise than the conventional Doppler method in evaluating MPI and single time intervals, because their measurements are accomplished in concomitance of left ventricular wall motion rather than the flow movement.
Federico Cacciapuoti; Domenico Galzerano; Paolo Capogrosso; Alessandro Arciello; Domenico Liberti; Fulvio Cacciapuoti; Diana Lama
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  22     ISSN:  0742-2822     ISO Abbreviation:  Echocardiography     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-20     Completed Date:  2005-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  IM    
Division of Internal Medicine and Metabolic Disease, Second University of Naples, Naples, Italy.
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MeSH Terms
Case-Control Studies
Echocardiography, Doppler, Pulsed*
Heart Function Tests
Hemodynamics / physiology
Lupus Erythematosus, Systemic / complications*,  diagnosis
Middle Aged
Myocardial Contraction / physiology*
Prospective Studies
Reference Values
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Stroke Volume / physiology
Ventricular Dysfunction, Left / complications*,  diagnosis,  ultrasonography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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