Document Detail

Impairment of jacalin binding to serum IgA in IgA nephropathy.
MedLine Citation:
PMID:  2313468     Owner:  NLM     Status:  MEDLINE    
A test was set up to analyze the direct binding of serum IgA to the lectin jacalin. Under the testing conditions, jacalin bound to both IgA subclasses and reacted similarly with monomeric and polymeric IgA. A jacalin index was defined to quantify serum IgA binding to this lectin. The jacalin index appeared significantly lower in IgA nephropathy than in controls. This may be related to abnormal IgA glycosylation, which could explain, at least in part, the mesangial deposition responsible for the renal disease.
P M Andre; P Le Pogamp; D Chevet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical laboratory analysis     Volume:  4     ISSN:  0887-8013     ISO Abbreviation:  J. Clin. Lab. Anal.     Publication Date:  1990  
Date Detail:
Created Date:  1990-04-26     Completed Date:  1990-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8801384     Medline TA:  J Clin Lab Anal     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-9     Citation Subset:  IM    
Laboratory of Microbiology, University Hospital, Rennes, France.
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MeSH Terms
Binding Sites
Enzyme-Linked Immunosorbent Assay
Glomerulonephritis, IGA / blood,  immunology*
Immunoglobulin A / classification,  metabolism*
Lectins / blood*
Middle Aged
Plant Lectins*
Reg. No./Substance:
0/Immunoglobulin A; 0/Lectins; 0/Plant Lectins; 0/jacalin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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