Document Detail

Impairment in orthostatic tolerance during heat exposure in individuals with Type I and Type II diabetes.
MedLine Citation:
PMID:  15795694     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Diabetes is often associated with orthostatic hypotension and temperature intolerance. Studies have examined either one stress or the other and not both to see if the stresses are additive. MATERIAL/METHODS: Eight subjects with Type 1 and 12 subjects with Type 2 diabetes and 15 controls were tested for orthostatic intolerance during a vertical tilt in a thermally neutral environment (22 degrees C) and a warm room (42 degrees C). Blood pressure, cardiac output, stroke volume, heart rate, skin blood flow and skin and body temperature were recorded. RESULTS: All subjects experienced reductions in their cardiac output and blood pressure when tilted. In the warmer environment, significant impairments in the compensatory blood pressure response and redistribution of cardiac output were found in subjects with diabetes. When tilted to the vertical posture, subjects with diabetes experienced reductions of about 10 mmHg in systolic blood pressure in the cool environment, and a reduction of 21 mmHg when tilted in the warm environment. The fall in the systolic pressure in the subjects with diabetes was accompanied by corresponding reductions in stroke volume and cardiac output (from 5.06 L/min to 4.75 L/min) but no change in the heart rate. To compensate for a vertical tilt, skin blood flow was reduced by about half in the controls but there was only a small vasoconstriction in the subjects with diabetes. CONCLUSIONS: Individuals with Type 1 and Type 2 diabetes, while showing some loss in orthostatic tolerance in a cool environment, showed significant clinical impairment associated with heat exposure.
Jerrold Scott Petrofsky; Chris Besonis; David Rivera; Ernie Schwab; Scott Lee
Related Documents :
16195134 - Orthostatic side effects of clomipramine and moclobemide during treatment for depression.
2494874 - Plasma norepinephrine in chagas' cardioneuromyopathy: a marker of progressive dysautono...
19672674 - Hyperventilation during orthostatic challenge in spinal cord-injured humans.
7042594 - Duration of the hypotensive effect of guanfacine.
3918464 - Cardiovascular responses to elevation of intra-abdominal hydrostatic pressure.
2468974 - Double-blind studies of calcium antagonists in the treatment of hypertension in japan.
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-03-24
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  11     ISSN:  1234-1010     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-06-07     Completed Date:  2005-06-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  CR153-9     Citation Subset:  IM    
Department of Physical Therapy and Internal Medicine, Loma Linda University, Loma Linda, CA 92350, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Flow Velocity
Blood Pressure
Body Temperature
Diabetes Mellitus, Type 1 / physiopathology*
Diabetes Mellitus, Type 2 / physiopathology*
Dizziness / physiopathology*
Hot Temperature*
Middle Aged
Reference Values
Skin / blood supply
Skin Temperature

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Neuromuscular control of physiological tremor during elastic load.
Next Document:  A two-phased population epidemiological study of the safety of thimerosal-containing vaccines: a fol...