Document Detail


Impairment in long-term memory formation and learning-dependent synaptic plasticity in mice lacking glycogen synthase in the brain.
MedLine Citation:
PMID:  23281428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glycogen is the only carbohydrate reserve of the brain, but its overall contribution to brain functions remains unclear. Although it has traditionally been considered as an emergency energetic reservoir, increasing evidence points to a role of glycogen in the normal activity of the brain. To address this long-standing question, we generated a brain-specific Glycogen Synthase knockout (GYS1(Nestin-KO)) mouse and studied the functional consequences of the lack of glycogen in the brain under alert behaving conditions. These animals showed a significant deficiency in the acquisition of an associative learning task and in the concomitant activity-dependent changes in hippocampal synaptic strength. Long-term potentiation (LTP) evoked in the hippocampal CA3-CA1 synapse was also decreased in behaving GYS1(Nestin-KO) mice. These results unequivocally show a key role of brain glycogen in the proper acquisition of new motor and cognitive abilities and in the underlying changes in synaptic strength.
Authors:
Jordi Duran; Isabel Saez; Agnès Gruart; Joan J Guinovart; José M Delgado-García
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-02
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  33     ISSN:  1559-7016     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-01     Completed Date:  2013-05-23     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  550-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
CA1 Region, Hippocampal / cytology,  enzymology*
CA3 Region, Hippocampal / cytology,  enzymology*
Cognition / physiology
Glycogen / genetics,  metabolism*
Glycogen Synthase / genetics,  metabolism*
Long-Term Potentiation / physiology
Memory, Long-Term / physiology*
Mice
Mice, Knockout
Motor Activity / physiology
Nerve Tissue Proteins / genetics,  metabolism*
Synapses / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 9005-79-2/Glycogen; EC 2.4.1.11/Glycogen Synthase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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