Document Detail


Impairment in kidney tubular function in patients receiving tenofovir is associated with higher tenofovir plasma concentrations.
MedLine Citation:
PMID:  20299966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tenofovir (TFV) is a nucleotide analogue active against HIV and hepatitis B virus. Although TFV rarely affects the glomerular function, abnormalities in the kidney tubular function appear to be quite common. The relationship between TFV exposure and kidney tubular dysfunction (KTD) was examined prospectively in 92 HIV-infected individuals. Median TFV plasma trough concentration was higher in patients with KTD than in the rest (182 vs. 106 ng/ml; P = 0.001). This dose-dependent effect further supports an involvement of TFV in KTD.
Authors:
Sonia Rodríguez-Nóvoa; Pablo Labarga; Antonio D'avolio; Pablo Barreiro; Marta Albalate; Eugenia Vispo; Carmen Solera; Marco Siccardi; Stefano Bonora; Giovanni Di Perri; Vincent Soriano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS (London, England)     Volume:  24     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  1064-6     Citation Subset:  IM; X    
Affiliation:
Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adenine / adverse effects,  analogs & derivatives*,  blood
HIV Infections / blood,  drug therapy*
Humans
Kidney Diseases / chemically induced*
Kidney Function Tests
Kidney Tubules / drug effects,  injuries
Phosphonic Acids / adverse effects*,  blood
Reverse Transcriptase Inhibitors / adverse effects*,  blood
Chemical
Reg. No./Substance:
0/Phosphonic Acids; 0/Reverse Transcriptase Inhibitors; 107021-12-5/tenofovir; 73-24-5/Adenine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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