| Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function. | |
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MedLine Citation:
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PMID: 8513969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evidence is increasing for small-vessel disease and disturbance of endothelium-dependent vasodilation in diabetic patients. The aim of this study was to compare coronary circulation in 11 diabetic patients (6 type I and 5 type II) and 7 control subjects. All patients had normal left ventricular systolic function and angiographically normal coronary arteries. To evaluate the maximal area of coronary microcirculation, coronary vascular reserve was determined by intracoronary Doppler and a maximally vasodilating dose of intracoronary papaverine (peak-to-resting coronary flow velocity ratio). To assess coronary endothelial function responses to stepwise intracoronary infusion of acetylcholine (10(-8) to 10(-5) M coronary estimated concentrations) were analyzed on four different segments in each patient by quantitative angiography. Peak-to-resting coronary flow velocity ratio was lower in diabetic patients than in control subjects (3.9 +/- 0.9 and 5.0 +/- 0.7, respectively, P < 0.02). Acetylcholine did not produce any diameter change at 10(-8) and 10(-7) M, but a progressive diameter reduction was observed at 10(-6) and 10(-5) M (-8.0 +/- 15.2%, P < 0.02 and -24.0 +/- 13.6%, P < 0.001, respectively). In control subjects, a progressive diameter dilation was produced from 10(-8) to 10(-6) M acetylcholine (5.1 +/- 3.4, 12.1 +/- 7.0, and 16.4 +/- 7.3%, respectively, all P < 0.001), and a moderate reduction was observed at 10(-5) M (-4.9 +/- 7.5%, P < 0.02). In the two groups, all segments dilated similarly after intracoronary isosorbide dinitrate.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A Nitenberg; P Valensi; R Sachs; M Dali; E Aptecar; J R Attali |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diabetes Volume: 42 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-07-19 Completed Date: 1993-07-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1017-25 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiac Investigation, CHU Xavier-Bichat, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology* Adult Analysis of Variance Blood Flow Velocity / drug effects Blood Pressure / drug effects Coronary Angiography Coronary Circulation* / drug effects Coronary Vessels / drug effects*, physiology, physiopathology Diabetes Mellitus / blood, physiopathology* Diabetes Mellitus, Type 1 / physiopathology Diabetes Mellitus, Type 2 / physiopathology Diabetic Angiopathies / blood, physiopathology* Dose-Response Relationship, Drug Echocardiography Female Heart Rate / drug effects Humans Male Middle Aged Muscle, Smooth, Vascular / drug effects, physiology, physiopathology Reference Values Systole Vascular Resistance / drug effects Vasodilation / drug effects* Ventricular Function, Left* |
| Chemical | |
Reg. No./Substance:
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51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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