Document Detail


Impairment of cellular and humoral immunity in overweight Mongolian gerbils (Meriones unguiculatus).
MedLine Citation:
PMID:  22182327     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Animal immunity is usually impaired in obesity. We know little about the effect of being overweight or obese on the immune function of wild rodents. The present study is aimed to test the hypothesis that immunity is suppressed in overweight Mongolian gerbils (Meriones unguiculatus). In the study, 16 overweight (body mass: 90.8-127.6 g) and 16 lean gerbils (body mass: 60.5-77.7 g) were randomly selected from a total of 174 male gerbils (body mass range: 55.8-144.7 g). Half of the overweight and lean males were injected with sterile saline; the others were immunochallenged (IC) with phytohaemagglutinin and keyhole limpet hemocyanin to assess cellular and humoral immunity, respectively. Body fat mass, wet and dry spleen mass, leukocyte counts, blood glucose levels and serum leptin levels were significantly higher in the overweight gerbils than in the lean gerbils. However, phytohemagglutinin response indicative of cellular immunity and immunoglobulin G concentrations was significantly lower in the IC overweight gerbils than in the IC lean gerbils. These results indicate that cellular and humoral immunity are impaired in the overweight gerbils. Excessive body fat mass, higher leukocyte counts and serum leptin levels imply that overweight gerbils are in a low grade inflammatory state.
Authors:
Deli Xu; Xinyu Liu; Dehua Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Integrative zoology     Volume:  6     ISSN:  1749-4877     ISO Abbreviation:  Integr Zool     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101492420     Medline TA:  Integr Zool     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  352-65     Citation Subset:  IM    
Copyright Information:
© 2011 ISZS, Blackwell Publishing and IOZ/CAS.
Affiliation:
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China College of Life Sciences, Qufu Normal University, Qufu, China.
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