Document Detail

Impairment of cell-mediated immunity in Pseudomonas aeruginosa pyelonephritis: lack of suppressor cell activity in vivo.
MedLine Citation:
PMID:  6219276     Owner:  NLM     Status:  MEDLINE    
Bacterial pyelonephritis was induced in mice by direct microinoculation of Pseudomonas aeruginosa in the kidney. In the acute phase of P. aeruginosa pyelonephritis, a state of cell-mediated immunity impairment, evaluated both in vitro as lymphocyte reactivity to concanavalin A and in vivo as host versus graft reaction has been observed. Furthermore, delayed-type hypersensitivity to specific bacterial antigen has been detected only when the kidney infection was subsiding, i.e., 3 weeks after bacteria inoculation. When investigating the mechanism of such T-cell impairment, we were unable to transfer the immunodepression, suggesting that suppressor cells are not involved in vivo. The role of P. aeruginosa inhibition of cell-mediated immunity in the pyelonephritic host is discussed.
V Colizzi; M Campa; C Garzelli; L Toca; G Bevilacqua; G Falcone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical microbiology and immunology     Volume:  171     ISSN:  0300-8584     ISO Abbreviation:  Med. Microbiol. Immunol.     Publication Date:  1982  
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  0314524     Medline TA:  Med Microbiol Immunol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  123-33     Citation Subset:  IM    
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MeSH Terms
Host vs Graft Reaction
Hypersensitivity, Delayed
Mice, Inbred CBA
Pseudomonas Infections / immunology*
Pyelonephritis / immunology*
T-Lymphocytes / immunology*
T-Lymphocytes, Regulatory / immunology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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