| Impairment of cell-mediated immunity in Pseudomonas aeruginosa pyelonephritis: lack of suppressor cell activity in vivo. | |
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MedLine Citation:
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PMID: 6219276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bacterial pyelonephritis was induced in mice by direct microinoculation of Pseudomonas aeruginosa in the kidney. In the acute phase of P. aeruginosa pyelonephritis, a state of cell-mediated immunity impairment, evaluated both in vitro as lymphocyte reactivity to concanavalin A and in vivo as host versus graft reaction has been observed. Furthermore, delayed-type hypersensitivity to specific bacterial antigen has been detected only when the kidney infection was subsiding, i.e., 3 weeks after bacteria inoculation. When investigating the mechanism of such T-cell impairment, we were unable to transfer the immunodepression, suggesting that suppressor cells are not involved in vivo. The role of P. aeruginosa inhibition of cell-mediated immunity in the pyelonephritic host is discussed. |
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Authors:
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V Colizzi; M Campa; C Garzelli; L Toca; G Bevilacqua; G Falcone |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical microbiology and immunology Volume: 171 ISSN: 0300-8584 ISO Abbreviation: Med. Microbiol. Immunol. Publication Date: 1982 |
Date Detail:
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Created Date: 1983-04-15 Completed Date: 1983-04-15 Revised Date: 2007-02-21 |
Medline Journal Info:
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Nlm Unique ID: 0314524 Medline TA: Med Microbiol Immunol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 123-33 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Host vs Graft Reaction Hypersensitivity, Delayed Mice Mice, Inbred CBA Pseudomonas Infections / immunology* Pyelonephritis / immunology* T-Lymphocytes / immunology* T-Lymphocytes, Regulatory / immunology* Time Factors |
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