Document Detail

Impairment of bile secretion induced by exhaustive exercise in the rat. Protective effects of S-adenosyl-L-methionine.
MedLine Citation:
PMID:  8325715     Owner:  NLM     Status:  MEDLINE    
The effects of strenuous exercise on the mechanisms of bile formation were studied in rats. Animals (n = 8) were exercised to exhaustion in a rodent treadmill at a speed of 24 m/min and a 12% slope. Hepatic glutathione concentration was significantly reduced (-40%) and liver malondialdehyde content significantly increased (+37%) when compared to sedentary controls (n = 6). Both serum alkaline phosphatase level and bile acid concentration were significantly higher in runners (+81% and +85%). Bile flow and the biliary secretion of bile acids were significantly reduced both in basal conditions and following an i.v. taurocholate infusion (0.5 mumol/min/100 g body wt). Biliary glutathione secretion was also significantly decreased following exercise. Cholestasis was caused by an impairment of both bile acid-dependent (BADF) and bile acid-independent fraction (BAIF) of bile flow (-25% and -29% respectively). Exercise caused a delay in the peak appearance time and a reduced biliary secretion of horseradish peroxidase, suggesting alterations in the functional integrity of the cytoskeleton. To test the protective effects of S-adenosyl-L-methionine (SAMe), rats received the drug for ten days at a daily dose of 8 mg/kg i.p. SAMe administration prevented hepatic glutathione depletion due to exercise, normalizing both bile flow and bile acid as well as glutathione secretion. Our results suggest that both glutathione depletion and alterations in fluidity and composition of hepatocyte membranes could contribute to the development of exercise-induced cholestasis.
J G Villa; M M Almar; P S Collado; E Llamazares; J González-Gallego
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of sports medicine     Volume:  14     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-08-09     Completed Date:  1993-08-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  IM    
Institute of Physical Education, University of León, Spain.
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MeSH Terms
Bile / drug effects,  secretion*
Bile Acids and Salts / secretion*
Cholestasis / etiology,  metabolism
Glutathione / drug effects,  metabolism
Liver / drug effects,  metabolism*,  physiopathology
Liver Function Tests
Physical Conditioning, Animal* / adverse effects
Physical Exertion / physiology*
Rats, Wistar
S-Adenosylmethionine / pharmacology*
Reg. No./Substance:
0/Bile Acids and Salts; 29908-03-0/S-Adenosylmethionine; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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