Document Detail

Impairment of autonomic reflexes in cirrhosis.
MedLine Citation:
PMID:  2309679     Owner:  NLM     Status:  MEDLINE    
Autonomic dysfunction may contribute to the hemodynamic disturbances in cirrhosis. Tests of autonomic function were performed in 20 patients with cirrhosis and 20 healthy subjects. The patients with severe cirrhosis (Child's grade B or C) had significant reductions in the Valsalva ratio, the heart rate variation during both facial immersion in water and deep breathing, the pressor response to forearm isometric exercise, and the heart rate response to dynamic exercise. The cold pressor test and the heart rate response to lying down were unaffected. These results indicate impairment of both sympathetic and parasympathetic reflexes in severe cirrhosis which may contribute to the hemodynamic disturbances of cirrhosis. Further studies are required to define the site of these defects.
A J MacGilchrist; J L Reid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  85     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-03     Completed Date:  1990-04-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  288-92     Citation Subset:  IM    
University Department of Materia Medica, Stobhill Hospital, Glasgow, Scotland, United Kingdom.
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MeSH Terms
Autonomic Nervous System / physiopathology*
Cold Temperature / diagnostic use
Exercise Test
Hemodynamics / physiology*
Liver Cirrhosis / blood,  physiopathology*
Middle Aged
Norepinephrine / blood
Prothrombin Time
Reflex / physiology*
Serum Albumin / metabolism
Valsalva Maneuver / physiology
Reg. No./Substance:
0/Serum Albumin; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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