| Impairment of autonomic reflexes in cirrhosis. | |
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MedLine Citation:
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PMID: 2309679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autonomic dysfunction may contribute to the hemodynamic disturbances in cirrhosis. Tests of autonomic function were performed in 20 patients with cirrhosis and 20 healthy subjects. The patients with severe cirrhosis (Child's grade B or C) had significant reductions in the Valsalva ratio, the heart rate variation during both facial immersion in water and deep breathing, the pressor response to forearm isometric exercise, and the heart rate response to dynamic exercise. The cold pressor test and the heart rate response to lying down were unaffected. These results indicate impairment of both sympathetic and parasympathetic reflexes in severe cirrhosis which may contribute to the hemodynamic disturbances of cirrhosis. Further studies are required to define the site of these defects. |
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Authors:
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A J MacGilchrist; J L Reid |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 85 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-04-03 Completed Date: 1990-04-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 288-92 Citation Subset: IM |
Affiliation:
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University Department of Materia Medica, Stobhill Hospital, Glasgow, Scotland, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Autonomic Nervous System / physiopathology* Cold Temperature / diagnostic use Exercise Test Hemodynamics / physiology* Humans Liver Cirrhosis / blood, physiopathology* Male Middle Aged Norepinephrine / blood Posture Prothrombin Time Reflex / physiology* Serum Albumin / metabolism Valsalva Maneuver / physiology |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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