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Impairment of alveolar type-II cells involved in the toxicity of Aflatoxin G(1) in rat lung.
MedLine Citation:
PMID:  22709786     Owner:  NLM     Status:  Publisher    
Our previous studies showed intragastric administration of Aflatoxin G(1) (AFG(1)) could induce lung adenocarcinoma, which derived from alveolar type II cells (AT-II cells). AT-II cells contribute to Aflatoxin B(1) (AFB(1)) metabolism and also serve as the potential progenitor cells for AFB(1)-induced tumorigenesis. Thus, AT-II cells may constitute a target for AFG(1) exposure and serve as progenitor cells for tumorigenesis induced by AFG(1). The current experiment was designed to identify the acute toxicity of AFG(1) in AT-II cells following a single intratracheal administration of AFG(1). We observed inflammatory changes in the alveolar septum at days 3 and 7 after AFG(1) treatment, which resolved by 14 days. We also found AFG(1) caused lamellar bodies damage in AT-II cells at days 3 and 7 post-treatment. Surfactant protein C (SP-C) expression, an AT-II cell-specific marker, was reduced at day 7 post-treatment. The structural and functional impairment in AT-II cells returned to normal by day 14. Moreover, we found that AFG(1) induced a elevation of intracellular calcium concentration [Ca(2+)]i in AT-II cells in vitro, which may contribute to the decreased SP-C expression. In conclusion, our results show AFG(1) induces structural and functional impairment in AT-II cells involved in the acute toxicity of AFG(1) in lung.
Haitao Shen; Ping Lv; Xin Xing; Lingxiao Xing; Xia Yan; Junling Wang; Xianghong Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-15
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  -     ISSN:  1873-6351     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Lab of Pathology, Hebei Medical University, Shijiazhuang, China.
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