| Impairment of T-regulatory cells in cord blood of atopic mothers. | |
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MedLine Citation:
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PMID: 18539197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Maternal atopy is a strong predictor for the development of childhood allergic diseases. The underlying mechanisms are ill defined, yet regulatory T (Treg) and T(H)17 cells may play a key role potentially shaping the early immune system toward a proallergic or antiallergic immune regulation. OBJECTIVE: We examined T(H)1/T(H)2, Treg, and T(H)17 cell responses to innate (lipid A/peptidoglycan) and mitogen/adaptive (phytohemagglutinin/Dermatophagoides pteronyssinus 1) immune stimulation in cord blood from offspring of atopic/nonatopic mothers. METHODS: Cord blood mononuclear cells from 161 healthy neonates (59% nonatopic, 41% atopic mothers) were investigated regarding Treg and T(H)17 cells (mRNA/surface markers), suppressive function, and proliferation/cytokine secretion. RESULTS: Cord blood from offspring of atopic mothers showed fewer innate-induced Treg cells (CD4(+)CD25(+)high), lower mRNA expression of associated markers (glucocorticoid-induced tumor necrosis factor receptor-related protein/lymphocyte activation gene 3; P < .05), and a trend toward lower Forkhead box transcription factor 3 (Foxp3) expression. Treg cell function was impaired in mitogen-induced suppression of T effector cells in cord blood of offspring from atopic mothers (P = .03). Furthermore, IL-10 and IFN-gamma secretion were decreased in innate-stimulated cord blood of offspring from atopic mothers (P = .04/.05). Innate-induced IL-17 was independent of maternal atopy and highly correlated with IL-13 secretion. CONCLUSION: In offspring of atopic mothers, Treg cell numbers, expression, and function were impaired at birth. T(H)17 cells were correlated with T(H)2 cells, independently of maternal atopy. |
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Authors:
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Bianca Schaub; Jing Liu; Sabine Höppler; Severine Haug; Christine Sattler; Anna Lluis; Sabina Illi; Erika von Mutius |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 121 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-09 Completed Date: 2008-07-01 Revised Date: 2008-12-10 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1491-9, 1499.e1-13 Citation Subset: AIM; IM |
Affiliation:
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Department of Pulmonary and Allergy, University Children's Hospital Munich, Munich, Germany. Bianca.Schaub@med.uni-muenchen.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD / biosynthesis Cytokines / biosynthesis Female Fetal Blood / cytology, immunology* Flow Cytometry Forkhead Transcription Factors / biosynthesis Gene Expression Humans Hypersensitivity, Immediate / immunology* Infant, Newborn / immunology* Male Mothers RNA, Messenger / analysis Receptors, Nerve Growth Factor / biosynthesis Receptors, Tumor Necrosis Factor / biosynthesis Reverse Transcriptase Polymerase Chain Reaction T-Lymphocyte Subsets / immunology* T-Lymphocytes, Regulatory / immunology* Transforming Growth Factor beta / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Cytokines; 0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/RNA, Messenger; 0/Receptors, Nerve Growth Factor; 0/Receptors, Tumor Necrosis Factor; 0/TNFRSF18 protein, human; 0/Transforming Growth Factor beta; 0/cytotoxic T-lymphocyte antigen 4 |
| Comments/Corrections | |
Comment In:
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J Allergy Clin Immunol. 2008 Oct;122(4):841; author reply 841
[PMID:
19014775
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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