Document Detail

Impaired vascular responses to nitroglycerin in subjects with coronary atherosclerosis.
MedLine Citation:
PMID:  11152844     Owner:  NLM     Status:  MEDLINE    
To study smooth muscle function in atherosclerosis, we calculated dose-response curves in patients with coronary artery disease and in controls by measuring changes in brachial artery diameter after incremental sublingual doses of nitroglycerin. The doses required to produce a 50% maximal dilator response were significantly higher in patients with coronary artery disease than in controls (p <0.002), suggesting smooth muscle dysfunction in atherosclerosis.
O T Raitakari; J P Seale; D S Celermajer
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  87     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-01     Completed Date:  2001-02-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  217-9, A8     Citation Subset:  AIM; IM    
Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia.
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MeSH Terms
Brachial Artery / drug effects,  ultrasonography
Coronary Artery Disease / drug therapy*
Dose-Response Relationship, Drug
Linear Models
Middle Aged
Muscle, Smooth, Vascular / drug effects*
Nitroglycerin / pharmacology*
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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