| Impaired transient vasodilation and increased vasoconstriction to digital local cooling in primary Raynaud's phenomenon. | |
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MedLine Citation:
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PMID: 21572005 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective. Raynaud's phenomenon (RP) is defined as episodic ischemia of the extremities in response to cold. Although the structure of skin capillaries is normal in primary RP, some data suggest impairment of microvascular function. We aimed at testing whether digital skin blood flow was lower in RP than in controls while cooling locally. We further evaluated the contribution of sensitive nerves in the response. Methods. We recruited 21 patients with primary RP and 20 healthy volunteers matched on age and gender. After a 10-min baseline at 33°C, skin temperature was cooled at 15°C or 24°C during 30 min on the forearm and the finger while monitoring perfusion with a custom-design laser Doppler flowmetry probe. Perfusion was also assessed after topical anesthesia. Blood flow was expressed as cutaneous vascular conductance (CVC). Data were subsequently expressed as area above the curve (AAC0-30) of the percentage decrease from baseline CVC (%BL). Results. CVC on the dorsum of the finger was lower in RP patients compared to controls at 15°C (AAC(0-30) were 106237.2 and 69544.3 %BL.s, respectively; P=0.02) and at 24°C (AAC(0-30) were 86915 and 57598 %BL.s, respectively; P=0.04) whereas we observed no significant difference on the finger pad and the forearm. Topical anesthesia increased CVC in patients with RP (P=0.05) whereas it did not affect reactivity in controls (P=0.86). Conclusion. Our study shows exaggerated skin microvascular vasoconstriction to local cooling on the dorsum of the finger in primary RP compared to controls. Part of this abnormal response in primary RP depends on sensitive nerves. |
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Authors:
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Matthieu Roustit; Sophie Blaise; Claire Millet; Jean-Luc Cracowski |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-13 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Grenoble University Hospital. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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