| Impaired thermoregulation in cold-exposed rats with hypothalamic obesity. | |
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MedLine Citation:
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PMID: 3020346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats with obesity-producing, hypothalamic knife cuts were fed a high fat diet and placed in the cold (2 degrees C) for six days starting 3, 11, or 24 days after surgery. Between surgery and cold exposure, knife-cut rats consumed 90% to 122% more energy and gained more weight (32 +/- 4, 112 +/- 5, and 241 +/- 9 g) than sham-operated rats (15 +/- 2, 34 +/- 2, and 58 +/- 3 g). When exposed to cold, sham-operated rats increased (22% to 30%) energy intake whereas knife-cut rats decreased (5% to 51%) intake. After 24 hours at 2 degrees C body temperatures of knife-cut rats were 1.2, 0.7, and 0.7 degrees less than those of control rats; body temperatures continued to decrease to 2.9, 3.0 and 2.5 degrees less than control rats after six days at 2 degrees C. Fasting for 12 hours at 2 degrees C caused a further reduction in body temperature to 4.9, 4.8, and 5.9 degrees less than in control rats. Cold exposure increased urinary excretion of norepinephrine and epinephrine (indicators of sympathoadrenal activity) in all rats. Guanosine diphosphate (GDP) binding to brown adipose tissue (BAT) mitochondria (an indicator of the thermogenic capacity of the tissue) was similar in cold-exposed, knife-cut, and sham-operated rats. Cold acclimation before hypothalamic knife-cut surgery prevented the cold-induced decrease in body temperatures of knife-cut rats.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J G Vander Tuig; J Kerner; K A Crist; D R Romsos |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 35 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-11-14 Completed Date: 1986-11-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 960-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, Brown
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metabolism Animals Body Temperature Regulation* Cold Temperature* Dopamine / urine Electron Transport Complex IV / metabolism Fasting Female Guanosine Diphosphate / metabolism Hypothalamus / physiology* Norepinephrine / urine Obesity / physiopathology* Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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AM 15847/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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146-91-8/Guanosine Diphosphate; 51-41-2/Norepinephrine; EC 1.9.3.1/Electron Transport Complex IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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