| Impaired thermoregulation against cold in capsaicin pretreated rats. | |
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MedLine Citation:
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PMID: 6657468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study was made of the effects of pretreatment with fractionated capsaicin on the changes in body temperature (Tb) induced in rats by exposure to cold and to warm environments, and by administration of histamine (40 mg X kg-1) or of pentobarbital (20 mg X kg-1). At the ambient temperature of 22 degrees C the Tb of capsaicin pretreated rats was lower than that of rats treated only with solvent (p less than 0.001). The capsaicin pretreated rats showed impairment of thermoregulation at both high and low environmental temperatures: their Tb rose to a higher level in a warm environment, while in a cold environment their Tb was lower than that of the control rats. Histamine and pentobarbital caused larger drops in the Tb of capsaicin pretreated rats than in the controls. These findings challenge the concept that capsaicin treatment acts exclusively on thermoregulatory mechanisms concerned with warmth sensation. |
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Authors:
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G Benedek; M Szikszay; F Obál |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 399 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1983 Nov |
Date Detail:
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Created Date: 1984-02-22 Completed Date: 1984-02-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 243-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects* Capsaicin / pharmacology* Cold Temperature Histamine / pharmacology Hot Temperature Male Pentobarbital / pharmacology Rats Rats, Inbred Strains / physiology Time Factors |
| Chemical | |
Reg. No./Substance:
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404-86-4/Capsaicin; 51-45-6/Histamine; 76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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