| Impaired systolic and diastolic function and ventricular arrhythmia are common in normotensive healthy elderly men with left ventricular hypertrophy. | |
| | |
MedLine Citation:
|
PMID: 10219517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The present study was designed to assess the impact of left ventricular hypertrophy (LVH) independent of hypertension on the presence of silent myocardial ischemia and arrhythmia, as well as on systolic and diastolic function in otherwise healthy elderly men. METHODS AND RESULTS: Twenty apparently healthy normotensive subjects with LVH were compared with 18 hypertensive subjects with LVH and with 20 healthy subjects without LVH (controls)--all recruited from a health screening programme of 70-year-old men. All participants were free from known coronary heart disease and were evaluated by means of echocardiography with Doppler, a symptom-limited exercise test and 24 h ambulatory ECG monitoring. The healthy normotensive subjects with LVH showed impaired systolic function (ejection fraction 66 +/- 8 (SD)% versus 72 +/- 8% in controls, P < 0.03) and impaired diastolic function (E/A ratio 0.86 +/- 0.20 versus 1.12 +/- 0.30, P < 0.01) as well as an increased number of premature ventricular complexes in the exercise test and during the 24 h ECG monitoring (P < 0.05), when compared with the healthy group without LVH. The hypertensive subjects with LVH showed impaired diastolic function (P < 0.05) and a more pronounced ST depression in the exercise test (P < 0.05), when compared with the healthy group without LVH. In both of the LVH groups, more than 20% of the subjects evidenced ST-segment depression > or = 1 mm in the exercise test, compared with 5% of the healthy group without LVH. CONCLUSIONS: In elderly men free from hypertension or other known disease, LVH at echocardiography was associated with impaired systolic and diastolic function as well as with ventricular arrhythmia. Thus, even in the absence of hypertension, LVH may be a harmful characteristic in the elderly. |
| | |
Authors:
|
B Andrén; L Lind; G Hedenstierna; H Lithell |
Related Documents
:
|
2987137 - Chronic alpha-adrenoceptor blockade with trimazosin in congestive heart failure. 446167 - Ventricular arrhythmias during exercise testing, jogging, and sedentary life: a compara... 910717 - Echocardiographic study of cardiac dimensions and function in the endurance-trained ath... 3391187 - Contraindications to physical training in patients with impaired ventricular function. 16046917 - Development of an exercise testing protocol for patients with a lower limb amputation: ... 7573437 - Splanchnic and muscle metabolism during exercise in niddm patients. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Coronary artery disease Volume: 10 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 1999 |
Date Detail:
|
Created Date: 1999-06-25 Completed Date: 1999-06-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 111-7 Citation Subset: IM |
Affiliation:
|
Department of Clinical Physiology, University of Uppsala, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Diastole / physiology* Electrocardiography, Ambulatory Exercise Test Follow-Up Studies Humans Hypertrophy, Left Ventricular / physiopathology*, ultrasonography Male Reproducibility of Results Retrospective Studies Systole / physiology* Tachycardia, Ventricular / physiopathology*, ultrasonography Ultrasonography, Doppler Ventricular Function, Left |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultrasonic videodensitometric analysis in scleroderma heart disease.
Next Document: Effects of low feed intake and hot environment on plasma profiles of glucose, nonesterified fatty ac...