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Impaired sustained attention in euthymic bipolar disorder patients and non-affected relatives: an fMRI study.
MedLine Citation:
PMID:  23036083     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Sepede G, De Berardis D, Campanella D, Perrucci MG, Ferretti A, Serroni N, Moschetta FS, Del Gratta C, Salerno RM, Ferro FM, Di Giannantonio M, Onofrj M, Romani GL, Gambi F. Impaired sustained attention in euthymic bipolar disorder patients and non-affected relatives: an fMRI study. Bipolar Disord 2012: 00: 000-000. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S. Objective:  Behavioral deficits in sustained attention have been reported during both acute and euthymic phases of type I bipolar disorder (BD-I) and also in non-affected relatives of bipolar disorder (BD) patients. In particular, selective failure in target recognition was proposed as a potential trait marker for BD, but there are few studies exploring the neural correlates. The aim of the present study was to analyze the behavioral and functional magnetic resonance imaging (fMRI) response of euthymic BD-I patients and non-affected relatives during a sustained attention task. Methods:  Twenty-four euthymic BD-I patients, 22 non-affected first-degree relatives of BD-I subjects, and 24 matched controls underwent a continuous performance test (CPT) with two levels of difficulty during event-related fMRI scanning. Results:  Both patients and relatives showed a lower accuracy in target detection when compared to controls. The fMRI data analysis revealed between-group differences in several brain regions involved in sustained attention. During error in target recognition, both patients and relatives showed a larger activation in the bilateral insula and the posterior part of the middle cingulate cortex. By contrast, during correct target response, only patients failed to activate the right insula, whereas relatives showed an increased activation of the left insula and bilateral inferior parietal lobule - limited to the higher attention load - and an augmented deactivation of the posterior cingulate/retrosplenial cortex. Conclusions:  A selective impairment in target recognition during a CPT was behaviorally and functionally detectable in both euthymic BD-I patients and non-affected first-degree relatives, suggesting that specific sustained attention deficits may be a potential trait marker for BD-I.
Authors:
Gianna Sepede; Domenico De Berardis; Daniela Campanella; Mauro Gianni Perrucci; Antonio Ferretti; Nicola Serroni; Francesco Saverio Moschetta; Cosimo Del Gratta; Rosa Maria Salerno; Filippo Maria Ferro; Massimo Di Giannantonio; Marco Onofrj; Gian Luca Romani; Francesco Gambi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-5
Journal Detail:
Title:  Bipolar disorders     Volume:  -     ISSN:  1399-5618     ISO Abbreviation:  Bipolar Disord     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883596     Medline TA:  Bipolar Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley and Sons A/S.
Affiliation:
Department of Neuroscience and Imaging, University of Chieti, Chieti National Health Trust, Department of Mental Health, Teramo ITAB-Institute for Advanced Biomedical Technologies, Foundation University `G. D' Annunzio', Chieti, Italy.
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