Document Detail


Impaired spermatogenesis in testes at risk of torsion.
MedLine Citation:
PMID:  3768659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The oligospermia observed after unilateral torsion of the spermatic cord could reflect immunological damage to the opposite testis. An alternative explanation, that there may be a pre-existing defect in spermatogenesis, was tested in 20 post-pubertal males with acute torsion. In a prospective study the contralateral testis was biopsied at operation and the histological appearances were related to subsequent testicular function as assessed by seminal analysis 3 months later. Thirteen patients had biopsy evidence of partial maturation arrest in spermatogenesis which was either mild (6), moderate (4) or severe (3), and ten of these were oligospermic (less than 20 X 10(6)/ml). By contrast all seven patients with normal histology had a sperm concentration greater than 25 X 10(6)/ml. Histological grading of spermatogenesis by the Johnsen technique gave a higher score in patients with a normal biopsy (median 9.01, semi-quartile range 8.96-9.21) than in those with abnormal histology (median 8.28, semi-quartile range 7.98-8.45, P less than 0.001) and correlated with the log of the sperm concentration 3 months later (r = 0.79, P less than 0.001). There was minimal anti-sperm and no anti-testis antibody formation following torsion. Serum FSH levels were raised in 6 of 10 oligospermic patients, while all those with a normal sperm count had FSH concentrations within the normal range. Thus many patients who develop testicular torsion have an underlying defect in spermatogenesis, which correlates closely with poor postoperative exocrine function.
Authors:
J B Anderson; M J Cooper; W E Thomas; R C Williamson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of surgery     Volume:  73     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-12-09     Completed Date:  1986-12-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  847-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies / analysis
Gonadotropins, Pituitary / blood
Humans
Male
Semen
Spermatic Cord Torsion / immunology,  physiopathology*,  surgery
Spermatogenesis*
Testis / immunology,  physiopathology*
Testosterone / blood
Chemical
Reg. No./Substance:
0/Antibodies; 0/Gonadotropins, Pituitary; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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